{"id":14803,"date":"2018-03-09T09:01:39","date_gmt":"2018-03-09T09:01:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-inestabilidad-de-microsatelites-y-mutaciones-en-el-oncogen-k-ras-en-el-cancer-colorrectal-esporadico\/"},"modified":"2018-03-09T09:01:39","modified_gmt":"2018-03-09T09:01:39","slug":"valor-pronostico-de-la-inestabilidad-de-microsatelites-y-mutaciones-en-el-oncogen-k-ras-en-el-cancer-colorrectal-esporadico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-de-la-inestabilidad-de-microsatelites-y-mutaciones-en-el-oncogen-k-ras-en-el-cancer-colorrectal-esporadico\/","title":{"rendered":"Valor pron\u00f3stico de la inestabilidad de microsat\u00e9lites y mutaciones en el oncogen k-ras en el c\u00e1ncer colorrectal espor\u00e1dico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Oliart Delgado De Torres Soledad <\/strong><\/h2>\n<p>En una serie conocida de c\u00e1ncer colorrectal, se han estudiado las alteraciones gen\u00e9ticas t\u00edpicas de las dos v\u00edas de tumorog\u00e9nesis colorrectal y que caracterizan los dos tipos \u00abcl\u00e1sicos\u00bb de s\u00edndromes hereditarios: poliposis adenomatosa familiar (v\u00eda supresora) y s\u00edndrome de lynch (v\u00eda mutadora). La inestabilidad de microsat\u00e9lites tumoral se ha analizado siguiendo los criterios estandarizados y se ha estudiado la relaci\u00f3n de los tumores inestables (msi-h) con alteraciones (loh) en los genes de la v\u00eda mutadora: hmlh1 y hmsh2 y de la v\u00eda supresora, en la que se han estudiado tanto perdidas de heterocigosidad (loh) de genes supresores: apc, tp53 y dcc, como mutaciones del oncogen k-ras, llegando a distintas conclusiones entre las que destacar\u00eda que los tumores espor\u00e1dicos msi+, a\u00fan siendo poco frecuentes (8,4%), pueden constituir un subgrupo diferenciado respecto a sus caracter\u00edsticas cl\u00ednico-patol\u00f3gicas: pacientes m\u00e1s j\u00f3venes, localizaci\u00f3n preferente en colon derecho, se suelen asociar con tumores b y c de dukes, rara vez metastatizan y suelen tener una mayor supervivencia; se asocian significativamente a lohs en el gen reparador hmsh2, y adem\u00e1s, muestran una asociaci\u00f3n a lohs del gen supresor iniciador de la v\u00eda supresora, el apc; sin embargo es independiente de las perdidas de heterocigosidad en tp53 y dcc, y de las mutaciones del oncog\u00e9n k-ras, lo cual resalta, que tambi\u00e9n en tumores espor\u00e1dicos existen dos v\u00edas de tumorog\u00e9nesis.  los tumores que presentan mutaci\u00f3n en el oncog\u00e9n k-ras y las distintas variables cl\u00ednico-patol\u00f3gicas estudiadas, en el estudio se comprueba que los tumores mutados tienden a darse en pacientes de mayor edad, a localizarse en el colon distal, y suelen detectarse en tumores con estadios de dukes m\u00e1s avanzados. Al estudiar la supervivencia de los pacientes cabe destacar que tanto las mujeres con mutaci\u00f3n k-ras (p=0,05), como los tumores proximales con mutaci\u00f3n k-ras (p&lt;0,00001<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pron\u00f3stico de la inestabilidad de microsat\u00e9lites y mutaciones en el oncogen k-ras en el c\u00e1ncer colorrectal espor\u00e1dico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pron\u00f3stico de la inestabilidad de microsat\u00e9lites y mutaciones en el oncogen k-ras en el c\u00e1ncer colorrectal espor\u00e1dico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Oliart Delgado De Torres Soledad <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jos\u00e9 Gonz\u00e1lez Aguilera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Rodr\u00edguez montes <\/li>\n<li> Pape\u00f1a crespo Miguel angel (vocal)<\/li>\n<li>pedro Carda abella (vocal)<\/li>\n<li>Elena Fern\u00e1ndez ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oliart Delgado De Torres Soledad En una serie conocida de c\u00e1ncer colorrectal, se han estudiado las alteraciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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