{"id":14856,"date":"2018-03-09T09:01:44","date_gmt":"2018-03-09T09:01:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-poblacional-de-la-gentamicina-de-neonatos\/"},"modified":"2018-03-09T09:01:44","modified_gmt":"2018-03-09T09:01:44","slug":"farmacocinetica-poblacional-de-la-gentamicina-de-neonatos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-poblacional-de-la-gentamicina-de-neonatos\/","title":{"rendered":"Farmacocin\u00e9tica poblacional  de la gentamicina de neonatos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Benito Garc\u00eda D\u00edaz <\/strong><\/h2>\n<p>Objetivos  1,- determinaci\u00f3n de los par\u00e1metros farmacocin\u00e9ticos poblacionales de la gentamicina en una poblaci\u00f3n de 500 neoatos neonatos ingresados en el hospital severo ochoa de legan\u00e9s (Madrid).  2,- establecimiento de los factores fisiopatol\u00f3gicos con mayor influencia sobre estos par\u00e1metros farmacocin\u00e9ticos.  3,- propuesta de un esquema de dosificaci\u00f3n que, basado en las caracter\u00edsticas espec\u00edficas individuales, optimece la eficacia y seguridad del tratamiento.  material y m\u00e9todos  la determinaci\u00f3n de los par\u00e1metros farmacocin\u00e9ticos poblaciones se realiz\u00f3 mediante el m\u00e9todo est\u00e1ndar en dos etapas (sts) y mediante el m\u00e9todo no lineal de efectos mixtos (nonmem). La influencia de los factores fisipatol\u00f3gicos se estableci\u00f3 mediante m\u00e9todos de regresi\u00f3n. La validaci\u00f3n de los modelos se realiz\u00f3 mediante el estudio de los errores de predicci\u00f3n.  resultados  por el m\u00e9todo sts se establecen modelos poblacionales para el aclaramiento sist\u00e9mico de gentamicina clg que incluyen los descriptores cl\u00ednicos de uso m\u00e1s habitual (edad gestacional eg, edad postnatal epn, peso pes y aclaramiento de creatinina llcr). La variabilidad interindividual asociada a este par\u00e1metro disminuye desde un valor inicial, sin predictores, del 36% a valores entre 25 y 28% en los modelos finales. En los modelos poblacionales del par\u00e1metro volumen de distribuci\u00f3n, solo se pueden introducir las variables eg y pes. por el m\u00e9todo nonmem y modelo monocompartimental, se identifican como variable de mayor influencia en el par\u00e1metro volumen de distribuci\u00f3n la eg. Como variables que determinan el clg se identifican el pes, la eg, la epn y el clcr. Los errores interindividuales como el error residual se ajustan a modelos aditivos, tomando valores comprendidos entre el 10 y el 25%. al considerar una distribuci\u00f3n bicompartimental de la gentamicina con el programa nonmem, se consigue una mejora significativa en la bondad de ajsute de los dato<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica poblacional  de la gentamicina de neonatos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica poblacional  de la gentamicina de neonatos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Benito Garc\u00eda D\u00edaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Molina Mart\u00ednez Irene T.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li>Manuel Guzm\u00e1n navarro (vocal)<\/li>\n<li>carmen Mar\u00eda Evora Garc\u00eda (vocal)<\/li>\n<li>Manuel Alos alimi\u00f1ana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Benito Garc\u00eda D\u00edaz Objetivos 1,- determinaci\u00f3n de los par\u00e1metros farmacocin\u00e9ticos poblacionales de la gentamicina en una poblaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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