{"id":14864,"date":"2018-03-09T09:01:45","date_gmt":"2018-03-09T09:01:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/asociaciones-de-los-genes-de-histocompatibilidad-y-de-las-caractera%c2%adsticas-cla%c2%adnicas-de-los-pacientes-con-esclerosis-multiple-de-la-provincia-de-malaga\/"},"modified":"2018-03-09T09:01:45","modified_gmt":"2018-03-09T09:01:45","slug":"asociaciones-de-los-genes-de-histocompatibilidad-y-de-las-caractera%c2%adsticas-cla%c2%adnicas-de-los-pacientes-con-esclerosis-multiple-de-la-provincia-de-malaga","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/asociaciones-de-los-genes-de-histocompatibilidad-y-de-las-caractera%c2%adsticas-cla%c2%adnicas-de-los-pacientes-con-esclerosis-multiple-de-la-provincia-de-malaga\/","title":{"rendered":"Asociaciones de los genes de histocompatibilidad y de las caracter\u00edsticas cl\u00ednicas de los pacientes con esclerosis m\u00faltiple de la provincia de m\u00e1laga"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Victoria Eugenia Fern\u00e1ndez S\u00e1nchez <\/strong><\/h2>\n<p>Introduccion  la esclerosis m\u00faltiple em han sido asociada con el haplotipo hla de clase ii, dr2 (drbi*501, dqa1*0102, dqb1*0602) en todas las poblaciones estudiadas excepto en la poblaci\u00f3n de cerde\u00f1a donde la em se encuentra asociada exclusivamente con dr4. Otras poblaciones (turqu\u00eda, islas canarias) muestran una asociaci\u00f3n secundaria con dr4 (drb1*04 dqa1*03 dqb1*0302). las asociaciones de los genes hla con las manifestaciones cl\u00ednicas de la enfermedad permanece controvertido. Adem\u00e1s,la em presenta una recurrencia familiar del 10-20%. La posibilidad de que la em familiar tenga rasgos cl\u00ednicos distintivos es objeto de controversia. Existen escasos datos sobre la preValencia y las caracter\u00edsticas cl\u00ednicas de la em familiar en espa\u00f1a. el 30% de pacientes con em tratados con interfer\u00f3n beta (ifnb) no muestran una clara respuesta positiva al tratamiento.  objetivos  1,- investigar la hip\u00f3tesis de que la em familiar es una enfermedad similar a la em espor\u00e1dica en la provincia de m\u00e1laga.  2,- investigar las posibles asociaciones hla de clase ii (drb1, dqa1 y dqb1) con la em en m\u00e1laga.  3,- investigar las posibles asociaciones del los alelos y haplotipos hla de clase ii con las caracter\u00edsticas cl\u00ednicas de la em.  4,- investigar las posibles diferencias cl\u00ednicas basales y de ant\u00edgenos de histocompatibilidad hla entre los pacientes sin beneficio cl\u00ednico del tratamiento con ifnb y los que s\u00ed lo presentan.  material y m\u00e9todos  pacientes: desde 1990 una cohorte de 634 pacientes consecutivos con em han sido seguidos prospectivamente en el hospital regional universitario carlos haya de m\u00e1laga. Durante el periodo 1998-2000 genotipamos 149 pacientes con em. Todos ten\u00edan progenitores espa\u00f1oles caucasoides, eran residentes en m\u00e1laga y ten\u00edan una em cl\u00ednicamente definida seg\u00fan los criterios de poser. Se buscaron activamente las familias con m\u00e1s de un caso de em, encontr\u00e1ndose 34 casos (5,4%) en 19 familias.Adem\u00e1s,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Asociaciones de los genes de histocompatibilidad y de las caracter\u00edsticas cl\u00ednicas de los pacientes con esclerosis m\u00faltiple de la provincia de m\u00e1laga<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Asociaciones de los genes de histocompatibilidad y de las caracter\u00edsticas cl\u00ednicas de los pacientes con esclerosis m\u00faltiple de la provincia de m\u00e1laga <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Victoria Eugenia Fern\u00e1ndez S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Alonso Ortiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Morell oca\u00f1a <\/li>\n<li>francisca Romero crespo (vocal)<\/li>\n<li>Jos\u00e9 Gutierrez fernandez (vocal)<\/li>\n<li> Reyes ya\u00f1ez Mar\u00eda  del pino (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Victoria Eugenia Fern\u00e1ndez S\u00e1nchez Introduccion la esclerosis m\u00faltiple em han sido asociada con el haplotipo hla de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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