{"id":14867,"date":"2018-03-09T09:01:45","date_gmt":"2018-03-09T09:01:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-geneticos-de-receptores-adhesivos-plaquetarios-y-cancer-de-mama\/"},"modified":"2018-03-09T09:01:45","modified_gmt":"2018-03-09T09:01:45","slug":"polimorfismos-geneticos-de-receptores-adhesivos-plaquetarios-y-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-geneticos-de-receptores-adhesivos-plaquetarios-y-cancer-de-mama\/","title":{"rendered":"Polimorfismos gen\u00e9ticos de receptores adhesivos plaquetarios y cancer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco De Asis Ayala De La Pe\u00f1a <\/strong><\/h2>\n<p>Introducci\u00f3n  la relaci\u00f3n existente entre plaquetas y comportamiento tumoral del c\u00e1ncer de mama puede resumirse en dos apartados: la participaci\u00f3n plaquetaria en los fen\u00f3menos de aparici\u00f3n de met\u00e1stasis y de progresi\u00f3n tumoral, medida por los mecanismos de agregaci\u00f3n plaquetaria inducida por c\u00e9lulas tumorales tcipa, y en segundo luagr, la existencia de mol\u00e9culas de adhesi\u00f3n con expresi\u00f3n com\u00fan en la superficie plaquetaria y en la superficie de las c\u00e9lulas tumorales (de forma aberrante o como consecuencia de su expresi\u00f3n normal en las c\u00e9lulas peiteliales). Las principales mol\u00e9culas de adhesi\u00f3n de este grupo o con participaci\u00f3n en la tcipa son la glicoprote\u00edna ib alfa y las integrinas alfa2, beta 1 y beta3 (que forma parte de la alfa iib beta3 y de la alfav y beta3). Para todas ellas se han descrito polimorfismos gen\u00e9ticos con potencial repercusi\u00f3n en su expresi\u00f3n o su funci\u00f3n para los que se han establecido relaciones con la patolog\u00eda tromb\u00f3tica. Dada la importancia de la integrinas en el comportamiento tumoral y la relaci\u00f3n de la tcipa con la aparici\u00f3n de met\u00e1stasis a distancia existe la posibilidad de que las modificaciones inducidas por estos polimorfismos gen\u00e9ticos puedan tener influencia en la aparici\u00f3n y la progresi\u00f3n de las neoplasias y en concreto del c\u00e1ncer de mama.  objetivos  determinaci\u00f3n de la relaci\u00f3n entre los polimorfismos gen\u00e9ticos de las mol\u00e9culas de adhesi\u00f3n con expresi\u00f3n plaquetaria y la aparici\u00f3n y el comportamiento biol\u00f3gico y cl\u00ednico del carcinoma de mama.  material y m\u00e9todos  se realiz\u00f3 un estudio de caso-control para cada polimorfismo gen\u00e9tico con un grupo de 101 pacientes diagnosticadas de c\u00e1ncer de mama y un grupo control de 101 mujeres sanas apareadas por edad con los casos.Se utiliz\u00f3 tambi\u00e9n un grupo m\u00e1s amplio individuos (entre 340 y 600, seg\u00fan el polimorfismo) para determinar la frecuencia de los polimorfismos en la poblaci\u00f3n general de nuestra \u00e1rea.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos gen\u00e9ticos de receptores adhesivos plaquetarios y cancer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos gen\u00e9ticos de receptores adhesivos plaquetarios y cancer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco De Asis Ayala De La Pe\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Corral De La Calle Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Garc\u00eda conde <\/li>\n<li>Miguel Mart\u00edn jim\u00e9nez (vocal)<\/li>\n<li>lorenzo Abad Martinez (vocal)<\/li>\n<li>\u00c1lvaro Rodr\u00edguez lescure (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco De Asis Ayala De La Pe\u00f1a Introducci\u00f3n la relaci\u00f3n existente entre plaquetas y comportamiento tumoral del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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