{"id":14942,"date":"2018-03-09T09:01:53","date_gmt":"2018-03-09T09:01:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-morfometrico-del-efecto-del-peptido-trefoil-tff3-en-un-modelo-experimental-de-enterocolitis-necrotizante\/"},"modified":"2018-03-09T09:01:53","modified_gmt":"2018-03-09T09:01:53","slug":"analisis-morfometrico-del-efecto-del-peptido-trefoil-tff3-en-un-modelo-experimental-de-enterocolitis-necrotizante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/analisis-morfometrico-del-efecto-del-peptido-trefoil-tff3-en-un-modelo-experimental-de-enterocolitis-necrotizante\/","title":{"rendered":"An\u00e1lisis morfom\u00e9trico del efecto del p\u00e9ptido trefoil tff3 en un modelo experimental de enterocolitis necrotizante."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosalia Carrasco Torrents <\/strong><\/h2>\n<p>La enterocolitis necrotizante (ecn) es una grave enfermedad digestiva que afecta a reci\u00e9n nacidos prematuros y de bajo peso, y que se caracteriza por la aparici\u00f3n de lesiones isqu\u00e9micas en el intestino delgado y colon. el p\u00e9ptido trefoil tff3 es expresado en condiciones normales por las c\u00e9lulas caliciformes del intestino delgado y colon y est\u00e1 implicado en el mantenimiento y en la reparaci\u00f3n de la mucosa gastrointestinal. Las formas monom\u00e9rica (tff3-ser57) y dim\u00e9rica (tff3-cis57) recombinantes de tff3 podr\u00edan prevenir y acelerar la curaci\u00f3n de las lesiones de la ecn.  m\u00e9todos  la ecn fue induc\u00edda en ratas de 18 d\u00edas de vida reci\u00e9n destetadas mediante oclusi\u00f3n de los vasos mesent\u00e9ricos superiores durante 60 minutos. Para examinar el efecto protector de tff3, se administr\u00f3 3 microgr\/gr de las formas monom\u00e9rica y dim\u00e9rica por v\u00eda subcut\u00e1nea y enteral 30 minutos despu\u00e9s de incidencia la reperfusi\u00f3n. Se tomaron muestras del intestino delgado y colon para an\u00e1lisis morfom\u00e9trico 3 horas despu\u00e9s del inicio de la reperfusi\u00f3n. la lesi\u00f3n mucosa fue valorada microsc\u00f3picamente de acuerdo con la puntuaci\u00f3n de chiu.  resultados  la isquemia caus\u00f3 denudaci\u00f3n de las vellosidades y necrosis tranmural focal. Las vesllosidades se acotaron, el \u00edndice de superficie disminuy\u00f3 y la puntuaci\u00f3n de chiu fue significativamente mayor. Las dos formas de tff3 redujeron el da\u00f1o de la mucosa cuando fueron administradas 30 minutos antes de la isquemia. En conjunto, la administraci\u00f3n de tff3-ser57 monom\u00e9ro y tffe3-cis57 d\u00edmero despu\u00e9s del inicio de la reperfusi\u00f3n promovi\u00f3 significativamente la curaci\u00f3n tanto en el intestino delgado como en el colon.  conclusiones  tanto el tff3-ser57 monom\u00e9ro como el tff3-cis57 d\u00edmero protegen a los animales de la enterocolitis necrotizante inducida mediante isquemia transitoria y tambi\u00e9n aceleran la curaci\u00f3n de las lesiones causadas por dicha isquemia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis morfom\u00e9trico del efecto del p\u00e9ptido trefoil tff3 en un modelo experimental de enterocolitis necrotizante.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis morfom\u00e9trico del efecto del p\u00e9ptido trefoil tff3 en un modelo experimental de enterocolitis necrotizante. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosalia Carrasco Torrents <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Morales Fochs<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Jimenez gonzalez <\/li>\n<li> Tovar larruecea Juan  Antonio (vocal)<\/li>\n<li>Jos\u00e9 Boix ochoa (vocal)<\/li>\n<li>Juli\u00e1n Pan\u00e9s d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosalia Carrasco Torrents La enterocolitis necrotizante (ecn) es una grave enfermedad digestiva que afecta a reci\u00e9n nacidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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