{"id":14990,"date":"2018-03-09T09:01:57","date_gmt":"2018-03-09T09:01:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-cot-quinasa-en-la-transicion-g1-s-de-celulas-t\/"},"modified":"2018-03-09T09:01:57","modified_gmt":"2018-03-09T09:01:57","slug":"implicacion-de-cot-quinasa-en-la-transicion-g1-s-de-celulas-t","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/implicacion-de-cot-quinasa-en-la-transicion-g1-s-de-celulas-t\/","title":{"rendered":"Implicaci\u00f3n de cot quinasa en la transici\u00f3n g1\/s de c\u00e9lulas t"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Velasco Sampayo <\/strong><\/h2>\n<p>Cot\/tpl-2 quinasa, hom\u00f3logo de miembros de la familia de prote\u00ednas quinasa quinasa quinasas activadas por mit\u00f3geneos (map3k), se descubri\u00f3 inicialmente por su capacidad de originar transformaci\u00f3n celular. Durante la fase g1 del ciclo celular de linfocitos t hay una inducci\u00f3n del mrna del proto-oncogen cot, hecho que indicar\u00eda la posibilidad de un papel de la quinasa en la transici\u00f3n g1\/s del ciclo celular de linfocitos t.  para estudiar el papel de cot quinasa en la transici\u00f3n g1\/s se utiliz\u00f3 la l\u00ednea celular ctll-2, la cual depende de il2 para crecer. La expresi\u00f3n transitoria de cot quinasa en estas c\u00e9lulas aumenta la s\u00edntesis de dna inducida por il2, mientras que la expresi\u00f3n del dominante negativo de esta quinasa reduce considerablemente la s\u00edntesis de dna inducida por dicha citoquina. Por otro lado, el an\u00e1lisis del ciclo celular de c\u00e9lulas ctll-2 que sobreexpresan cot quinasa de forma estable sincronizadas en fase g1, indica que esta quinasa contribuye a la progresi\u00f3n a fase s. Adem\u00e1s, cot quinasa reduce los niveles del inhibidor p24 kip1, mientras que los niveles de bcl-xl no se ven afectados.  por otra parte, esta quinasa disminuye los niveles de expresi\u00f3n de mrna de varios genes implicados en ciclo celular como el inhibidor p19 ink4d, las prote\u00ednas relacionadas con rb, p130 y p107 y genes implicados en apoptosis como fasr y bad. Otros genes como c-fos, elk-1, fyn o granzima a, sin embargo, tienen aumentado sus niveles de mrna por la actividad de cot quinasa. Cot tambi\u00e9n aumenta los niveles de mrna de e2f1, y adem\u00e1s se correlaciona con un incremento en la actividad transcripcional de e2f. Dicho aumento se da de manera independiente a pi3k, actuando cot de forma sin\u00e9rgica con esta quinasa. Todos estos datos dan evidencias, por primera vez, de la regulaci\u00f3n de distintos eventos de la progresi\u00f3n de la fase g1 por cot quinasa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de cot quinasa en la transici\u00f3n g1\/s de c\u00e9lulas t<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de cot quinasa en la transici\u00f3n g1\/s de c\u00e9lulas t <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Velasco Sampayo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Susana Alemany De La Pe\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Fresno <\/li>\n<li>isabel M\u00e9rida (vocal)<\/li>\n<li>sara Ballester (vocal)<\/li>\n<li>Luis \u00e1lvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Velasco Sampayo Cot\/tpl-2 quinasa, hom\u00f3logo de miembros de la familia de prote\u00ednas quinasa quinasa quinasas activadas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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