{"id":14999,"date":"2018-03-09T09:01:58","date_gmt":"2018-03-09T09:01:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-extincion-de-la-conducta-de-autoadministracion-de-cocaa%c2%adna-sobre-sistemas-glutamatergico-y-dopaminergico\/"},"modified":"2018-03-09T09:01:58","modified_gmt":"2018-03-09T09:01:58","slug":"efecto-de-la-extincion-de-la-conducta-de-autoadministracion-de-cocaa%c2%adna-sobre-sistemas-glutamatergico-y-dopaminergico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/psicologia\/efecto-de-la-extincion-de-la-conducta-de-autoadministracion-de-cocaa%c2%adna-sobre-sistemas-glutamatergico-y-dopaminergico\/","title":{"rendered":"Efecto de la extinci\u00f3n de la conducta de autoadministraci\u00f3n de coca\u00edna sobre sistemas glutamat\u00e9rgico y dopamin\u00e9rgico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Crespo Fern\u00e1ndez Jos\u00e9 Antonio <\/strong><\/h2>\n<p>A pesar de varias d\u00e9cadas de investigaci\u00f3n sobre los mecanismos de acci\u00f3n de la coca\u00edna, a\u00fan no disponemos del suficiente cuerpo de conocimientos que nos permita tener farmacoterapias adecuadas para el tratamiento de la dependencia de coca\u00edna. Esta droga act\u00faa sobre varios sistemas de neurotransmisores y principalmente, sobre el dopamin\u00e9rgico, opioid\u00e9rgico, glutamat\u00e9rgico, serotonin\u00e9rgico y el de crf (corticotropin releasing factor). En la presente tesis doctoral nos hemos centrado en el estudio de los efectos de la coca\u00edna sobre los sistemas glutamat\u00e9rgico y dopamin\u00e9rgico tras la autoadministraci\u00f3n intravenosa de esta droga y despu\u00e9s de la extinci\u00f3n de la conducta de autoadministraci\u00f3n intravenosa de esta droga y despu\u00e9s de la extinci\u00f3n de la conducta de autoadministraci\u00f3n de coca\u00edna.  empleando un dise\u00f1o de triadas, los tres animales de cada triada recibieron coca\u00edna (1mg\/kg):  1,- de forma contingente (el animal que autoadministraba)  2,- de forma no contingente (el animal que recib\u00eda la misma dosis de droga de forma pasiva cuando el que se autoadministraba lo hac\u00eda).  en un tercer grupo, los animales recibieron suero salino de forma no contingente, cuando el animal que se autoadministraba lo hac\u00eda. Este grupo de suero salino es el control de los otros dos de cocac\u00edna. Una vez estabilizada la conducta de autoadministraci\u00f3n de coca\u00edna, cuatro grupos de animales, denominados dia cero (\u00faltimo d\u00eda de autoadministraci\u00f3n); dia 1 (primer d\u00eda de extinci\u00f3n); dia 5 cinco d\u00edas de extinci\u00f3n) y dia 10 (d\u00edez d\u00edas de extinci\u00f3n), fueron sacrificados y sus cerebros procesados para autorradiograf\u00eda cuantitativa de receptores e hibridaci\u00f3n in situ.  los resultados indicaron que el sistema dopamin\u00e9rgico se afecta m\u00e1s que el glutamat\u00e9rgico durante la autoadministraci\u00f3n y la extinci\u00f3n de esta conducta de autoadministraci\u00f3n de coca\u00edna. Adem\u00e1s, la influencia de la droga fue m\u00e1s evidente en el grupo de ani<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la extinci\u00f3n de la conducta de autoadministraci\u00f3n de coca\u00edna sobre sistemas glutamat\u00e9rgico y dopamin\u00e9rgico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la extinci\u00f3n de la conducta de autoadministraci\u00f3n de coca\u00edna sobre sistemas glutamat\u00e9rgico y dopamin\u00e9rgico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Crespo Fern\u00e1ndez Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Nacional de educaci\u00f3n a distancia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Ambrosio Flores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  cruz Rodriguez del cerro <\/li>\n<li>Javier Fernandez ruiz (vocal)<\/li>\n<li>Miguel S\u00e1nchez turet (vocal)<\/li>\n<li>Luis Fernando Alguacil merino (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Crespo Fern\u00e1ndez Jos\u00e9 Antonio A pesar de varias d\u00e9cadas de investigaci\u00f3n sobre los mecanismos de acci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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