{"id":15002,"date":"2018-03-09T09:01:58","date_gmt":"2018-03-09T09:01:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-aportaciones-al-mecanismo-neurotoxico-de-las-34-metilendioximetanfetamina-mdma-extasis\/"},"modified":"2018-03-09T09:01:58","modified_gmt":"2018-03-09T09:01:58","slug":"nuevas-aportaciones-al-mecanismo-neurotoxico-de-las-34-metilendioximetanfetamina-mdma-extasis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevas-aportaciones-al-mecanismo-neurotoxico-de-las-34-metilendioximetanfetamina-mdma-extasis\/","title":{"rendered":"Nuevas aportaciones al mecanismo neurot\u00f3xico de las 3,4-metilendioximetanfetamina (mdma, \u00ab\u00e9xtasis\u00bb)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Iciar Hervias Aldama <\/strong><\/h2>\n<p>La 3,4-metilendioximetanfetamina es una droga de abuso que pertenece a las denominadas drogas de s\u00edntesis. El consumo de la mdma (\u00ab\u00e9xtasis\u00bb) se ha popularizado entre los j\u00f3venes bajo la creencia de que se trata de una droga segura, carente de riesgos para la salud del consumidor. Durante los \u00faltimos a\u00f1os han aparecido diversos estudios en los que se demuestra que el consumo de la mdma ocasiona diferentes alteraciones funcionales y de comportamiento. En animales de experimentaci\u00f3n la mdma produce diversos da\u00f1os neuronales y esta puede ser la causa de las alteraciones descritas en los consumidores. El mecanismo por el cual la mdma lesiona las terminales nerviosas serotonin\u00e9rgicas en la rata no ha sido dilucidado. Por esta raz\u00f3n, nos planteamos profundizar en los mecanismos implicados en la degeneraci\u00f3n de las terminales nerviosas serotonin\u00e9rgicas centr\u00e1ndonos en la fuente y los radicales espec\u00edficos implicados en el proceso neurot\u00f3xico.  debido a la escasez de estudios sobre la diferencia interespecie en el patr\u00f3n neurot\u00f3xico de la mdma, estudiamos si la neurotoxicidad dopamin\u00e9rgica que produce la mdma en el rat\u00f3n es, al igual que ocurre en la rata, debida a la producci\u00f3n de especies reactivas de ox\u00edgeno. Adem\u00e1s, intentamos dilucidar si la diferencia en el patr\u00f3n neurot\u00f3xico es debida a diferentes fuentes de producci\u00f3n de radicales o que el radical implicado sea distinto.  los datos obtenidos en esta tesis doctoral indican que el mecanismo neurot\u00f3xico de la mdma en la rata no es debido a un desequilibrio energ\u00e9tico ni a la dopamina liberada tras la administraci\u00f3n de la mdma y que probablemente sea alg\u00fan metabolito de la mdma formado en la periferia el responsable de la neurotoxicidad. En el rat\u00f3n, al igual que ocurre en la rata, la neurotoxicidad producida por la mdma es debida a un aumento en la formaci\u00f3n de radicales libres, sin embargo, ni el radical super\u00f3xido ni el per\u00f3xido de hidr\u00f3geno parecen ser los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevas aportaciones al mecanismo neurot\u00f3xico de las 3,4-metilendioximetanfetamina (mdma, \u00ab\u00e9xtasis\u00bb)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevas aportaciones al mecanismo neurot\u00f3xico de las 3,4-metilendioximetanfetamina (mdma, \u00ab\u00e9xtasis\u00bb) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Iciar Hervias Aldama <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Norberto Aguirre Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Florez beledo <\/li>\n<li>Mar\u00eda Jos\u00e9 Iraburu elizalde (vocal)<\/li>\n<li>Rafael Maldonado (vocal)<\/li>\n<li>edurne Cenarruzabeitia sagarminaga (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Iciar Hervias Aldama La 3,4-metilendioximetanfetamina es una droga de abuso que pertenece a las denominadas drogas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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