{"id":15019,"date":"2018-03-09T09:01:59","date_gmt":"2018-03-09T09:01:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-del-efecto-del-factor-de-crecimiento-similar-a-la-insulina-tipo-i-igf-i-en-la-fibrosis-hepatica\/"},"modified":"2018-03-09T09:01:59","modified_gmt":"2018-03-09T09:01:59","slug":"mecanismos-moleculares-del-efecto-del-factor-de-crecimiento-similar-a-la-insulina-tipo-i-igf-i-en-la-fibrosis-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-moleculares-del-efecto-del-factor-de-crecimiento-similar-a-la-insulina-tipo-i-igf-i-en-la-fibrosis-hepatica\/","title":{"rendered":"Mecanismos moleculares del efecto del factor de crecimiento similar a la insulina tipo i (igf-i) en la fibrosis hep\u00e1tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Sanz Hern\u00e1ndez <\/strong><\/h2>\n<p>La fibrosis hep\u00e1tica tiene lugar en respuesta a un da\u00f1o tipo viral, obstructivo, metab\u00f3lico &#8230;, Por el que las c\u00e9lulas hep\u00e1ticas (ceh) experimentan un proceso denominado \u00abactivaci\u00f3n\u00bb, aumentando la expresi\u00f3n de actina de m\u00fasculo liso tipo alfa (alfasma) as\u00ed como de mol\u00e9culas de matriz extracelular (mec). El factor de crecimiento similar a la insulina tipo i (igf-i) es secretado fundamentalmente por los hepatocitos, aunque sus acciones residen en otros tipos celulares, como ceh o c\u00e9lulas de kupffer (ck). Estas c\u00e9lulas son capaces de producir citoquinas y quimioquinas (mip-1alfa, tnfalfa, &#8230;) Que promueven la respuesta patol\u00f3gica del tejido. Se ha sugerido que el igf-i puede contribuir al proceso de activaci\u00f3n de las ceh, sin embargo, la administraci\u00f3n de bajas dosis de esta hormona mejora la respuesta hepatocelular frente al da\u00f1o. Con el objeto de evaluar el efecto de igf-i en la fibrosis hep\u00e1tica, se llev\u00f3 a cabo una administraci\u00f3n oral de ccl4 en rat\u00f3n wild-type (wt) y transg\u00e9nico que hiperexpresa el gen de igf-i dirigido por el promotor alfasma. La expresi\u00f3n del transg\u00e9n mejor\u00f3 la respuesta frente al da\u00f1o (funci\u00f3n hep\u00e1tica, necrosis, bcl-xl), redujo el grado de activaci\u00f3n de las ceh (alfasma), aceler\u00f3 la regeneraci\u00f3n hep\u00e1tica (brdu) y modul\u00f3 la expresi\u00f3n de genes relacionados con igf-i (igf-ir, igfbp-1) y con el proceso inflamatorio y fibrog\u00e9nico (col\u00e1geno alfa1(i), fibronectina, hgf, tgfbeta, tnfalfa, mip-1alfa, il-10). Los resultados del presente trabajo sugieren que el igf-i es un factor capaz de mejorar la respuesta del tejido frente al da\u00f1o, as\u00ed como de disminuir la producci\u00f3n de mec al reducir la expresi\u00f3n de tgfbeta1, y de modular la respuesta inflamatoria al regular la expresi\u00f3n de tnfalfa, mip-1alfa e il-10, por lo que debe considerarse como alternativa terap\u00e9utica en el da\u00f1o hep\u00e1tico y la inflamaci\u00f3n asociada al mismo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moleculares del efecto del factor de crecimiento similar a la insulina tipo i (igf-i) en la fibrosis hep\u00e1tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moleculares del efecto del factor de crecimiento similar a la insulina tipo i (igf-i) en la fibrosis hep\u00e1tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Sanz Hern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Manuel Rodr\u00edguez Ortigosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>Jorge  augusto Quiroga vilas (vocal)<\/li>\n<li>Jos\u00e9 Antonio Solis  herruzo (vocal)<\/li>\n<li>inmaculada Castilla cortazar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Sanz Hern\u00e1ndez La fibrosis hep\u00e1tica tiene lugar en respuesta a un da\u00f1o tipo viral, obstructivo, metab\u00f3lico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,17749],"tags":[48096,13077,15059,18372,22624,48095],"class_list":["post-15019","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-navarra","tag-carlos-manuel-rodriguez-ortigosa","tag-inmaculada-castilla-cortazar","tag-jesus-m-prieto-valtuena","tag-jorge-augusto-quiroga-vilas","tag-jose-antonio-solis-herruzo","tag-sonia-sanz-hernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15019"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15019\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}