{"id":15040,"date":"2002-10-01T00:00:00","date_gmt":"2002-10-01T00:00:00","guid":{"rendered":""},"modified":"2002-10-01T00:00:00","modified_gmt":"2002-10-01T00:00:00","slug":"estudio-cla%c2%adnicopatologico-y-quirurgico-retrospectivo-de-72-casos-de-dermatofibrosarcoma-protuberans-con-especial-referencia-al-valor-pronostico-de-la-cuantificacion-inmunohistoqua%c2%admica-del","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-cla%c2%adnicopatologico-y-quirurgico-retrospectivo-de-72-casos-de-dermatofibrosarcoma-protuberans-con-especial-referencia-al-valor-pronostico-de-la-cuantificacion-inmunohistoqua%c2%admica-del\/","title":{"rendered":"Estudio cl\u00ednicopatol\u00f3gico y quir\u00fargico retrospectivo de 72 casos de dermatofibrosarcoma protuberans, con especial referencia al valor pron\u00f3stico de la cuantificaci\u00f3n inmunohistoqu\u00edmica del \u00edndice de proliferaci\u00f3n celular y de la expresi\u00f3n del oncog\u00e9n p53"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jacobo Maiz Bescansa <\/strong><\/h2>\n<p>Los dermatofibrosarcomas protuberan (dfsp), son tumores fibrohistocitarios de la piel y tejidos blandos superficiales, cuyo comportamiento biol\u00f3gico es dif\u00edcil de predicir con los estudiso histopatol\u00f3gicos de rutina. La utilizaci\u00f3n de marcadores de biolog\u00eda tumoral en tumores malignos tales como los \u00edndices de proliferaci\u00f3n celular o la determinaci\u00f3n del oncog\u00e9n p53 pueden proporcionar una mayor informaci\u00f3n cerca del probable curso cl\u00ednico y tambi\u00e9n en la elecci\u00f3n del tratamiento a seguir.  se realiza una revisi\u00f3n de las t\u00e9cnicas inmunohistoqu\u00edmicas utilizadas y una puesta al d\u00eda del tumor (dfsp) objeto del estudio.  establecimiento de la hip\u00f3tesis  1,- probable comportamiento cl\u00ednico del dfsp y su capacidad metastizante en relaci\u00f3n con el \u00edndice de proliferaci\u00f3n celular.  2,- una mayor malignidad biol\u00f3gica en relaci\u00f3n con la expresi\u00f3n de oncog\u00e9n p53. Siendo esto cierto se podr\u00eda establecer como una definida y objetivable correlaci\u00f3n de estos dos factores con el comportamiento biol\u00f3gico y pron\u00f3stico de los dfsp.  material y m\u00e9todos  se utilizan 72 dfsp y anticuerpos anti-ki67 y anti pcna (para valorar el \u00edndice de proliferaci\u00f3n celular), monoclonal mib-1 (para el ant\u00edgeno nuclear ki67), monoclonal pc 10 (para valoraci\u00f3n del pcna) y el anticuerpo monoclonal mu 195 (para determinar el oncog\u00e9n p53), con controles cualitativos y cuantitativos para las t\u00e9cnicas inmunohistoqu\u00edmicas realizadas. La obtenci\u00f3n de datos cl\u00ednicos se lleva a cabo en esos 72 pacientes revisados en relaci\u00f3n a la presencia de recidivas, desarrollo de met\u00e1stasis, fecha de la \u00faltima revisi\u00f3n y tiempo de seguimiento cl\u00ednico. El an\u00e1lisis estad\u00edstico fue referenciado por resultados en frecuencias absolutas y %, as\u00ed como el estudio de la supervivencia.  resultados  se describen los resultados de los datos cl\u00ednicos y de seguimiento (diang\u00f3stico, tratamiento, y evoluci\u00f3n), en un per\u00edodo de 28 a\u00f1os y tambi\u00e9n los resul<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio cl\u00ednicopatol\u00f3gico y quir\u00fargico retrospectivo de 72 casos de dermatofibrosarcoma protuberans, con especial referencia al valor pron\u00f3stico de la cuantificaci\u00f3n inmunohistoqu\u00edmica del \u00edndice de proliferaci\u00f3n celular y de la expresi\u00f3n del oncog\u00e9n p53<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio cl\u00ednicopatol\u00f3gico y quir\u00fargico retrospectivo de 72 casos de dermatofibrosarcoma protuberans, con especial referencia al valor pron\u00f3stico de la cuantificaci\u00f3n inmunohistoqu\u00edmica del \u00edndice de proliferaci\u00f3n celular y de la expresi\u00f3n del oncog\u00e9n p53 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jacobo Maiz Bescansa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Varela Dur\u00e1n Juan  Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaqu\u00edn Potel lesquereux <\/li>\n<li> D\u00edaz torres Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Miguel Cainxos fern\u00e1ndez (vocal)<\/li>\n<li> De la fuente gonz\u00e1lez Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jacobo Maiz Bescansa Los dermatofibrosarcomas protuberan (dfsp), son tumores fibrohistocitarios de la piel y tejidos blandos superficiales, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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