{"id":15046,"date":"2002-10-01T00:00:00","date_gmt":"2002-10-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/senalizacion-diferencial-en-celulas-t-mutantes-en-tcr-beta-resistentes-a-apoptosis-estudio-de-intemediarios-tempranos-y-tardios\/"},"modified":"2002-10-01T00:00:00","modified_gmt":"2002-10-01T00:00:00","slug":"senalizacion-diferencial-en-celulas-t-mutantes-en-tcr-beta-resistentes-a-apoptosis-estudio-de-intemediarios-tempranos-y-tardios","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/senalizacion-diferencial-en-celulas-t-mutantes-en-tcr-beta-resistentes-a-apoptosis-estudio-de-intemediarios-tempranos-y-tardios\/","title":{"rendered":"Se\u00f1alizacion diferencial en celulas t mutantes en tcr beta resistentes a apoptosis: estudio de intemediarios tempranos y tardios"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Emma Teixeiro Pernas <\/strong><\/h2>\n<p>En esta tesis hemos tratado de profundizar en los mecanismos que hacen al tcr capaz de se\u00f1alizar diferencialmente. El receptor mutante en la transmembrana de tcrb es capaz de soportar algunas respuestas de la c\u00e9lula t pero es incapaz de inducir otras. Asi, hemos demostrado que (1) a traves de la estimulaci\u00f3n del tcrb mutante se diseccionan las se\u00f1ales que median la apoptosis (fasl) frente a las que median la proliferaci\u00f3n y secreci\u00f3n de citoquinas (il-2, ifny, tnfa). (2) los mecanismos que soportan el fenotipo funcional de las c\u00e9lulas mutantes se han podido adscribir a alteraciones bioquimicas seriadas, tanto a nivel de intermediarios tempranos como tardios. (3) el tcr mutante diversifica las rutas de se\u00f1alizaci\u00f3n desde los eventos m\u00e1s tempranos de la se\u00f1al y lo hace modulando tanto la actividad de intermediarios mediante la fosforilaci\u00f3n tyr como la ubicaci\u00f3n de los mismos en distintos compartimentos celulares. (4) tras estimulacion del recepotr mutante en tcrb se ven afectadas las se\u00f1ales que conducen a la activaci\u00f3n de nf-kb y de mapks, mientras que la induccion de nf-at permanece intacta. Adem\u00e1s, la mutaci\u00f3n en el dominio transmembrana de tcrb tiene importantes consecuencias para la biolog\u00eda de la celula t, y en concreto, para el fenomeno apoptotico puesto que las celulas mutantes son resistentes a la apoptosis inducida a trav\u00e9s de su tcr. El sistema experimental ha permitido (1) demostrar que nf-kb es esencial para la regulaci\u00f3n transcripcional de fasl, habiendo sido identificado un sitio funcionalmente activo en el promotor de dicha mol\u00e9cula inductora de muerte. (2) sugerir que jnk podrian estar involucradas en la regulaci\u00f3n temprana de la inducci\u00f3n de fasl de modo que deficiencias en las rutas de activaci\u00f3n de nf-kb, jnk y p38mapk podrian explicar la resistencia apopt\u00f3tica en las celulas mutantes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Se\u00f1alizacion diferencial en celulas t mutantes en tcr beta resistentes a apoptosis: estudio de intemediarios tempranos y tardios<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Se\u00f1alizacion diferencial en celulas t mutantes en tcr beta resistentes a apoptosis: estudio de intemediarios tempranos y tardios <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Emma Teixeiro Pernas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Bragado Herrero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>Manuel Izquierdo pastor (vocal)<\/li>\n<li>Antonio De la hera mart\u00ednez (vocal)<\/li>\n<li>Jaime Sancho lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Emma Teixeiro Pernas En esta tesis hemos tratado de profundizar en los mecanismos que hacen al tcr [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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