{"id":151303,"date":"2026-01-12T16:32:04","date_gmt":"2026-01-12T16:32:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/leucemia-linfatica-cronica-caracteristicas-clinicas-y-estudio-de-factores-pronosticos-de-supervivencia\/"},"modified":"2026-01-12T16:32:04","modified_gmt":"2026-01-12T16:32:04","slug":"leucemia-linfatica-cronica-caracteristicas-clinicas-y-estudio-de-factores-pronosticos-de-supervivencia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/leucemia-linfatica-cronica-caracteristicas-clinicas-y-estudio-de-factores-pronosticos-de-supervivencia\/","title":{"rendered":"Leucemia linfatica cronica: caracteristicas clinicas y estudio de factores pronosticos de supervivencia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isidro Jarque Ramos <\/strong><\/h2>\n<p>Se revisan 187 casos de llc-b, no tratados previamente, diagnosticados de 1969 a 1988. La edad media fue 65 a\u00f1os (extremos: 36-87). Habia 118 varones (v\/m= 1,7). Se clasificaron por estadios de rai (0: 29%, i: 20%, ii:  25%, iii: 13%, iv:13%)y de binet (a: 55%, b: 21%, c:  24%). Los hallazgos fisicos mas frecuentes fueron:  adenopatias (55%), esplenomegalia (32%) y hepatomegalia (28%). Se encontro anemia en el 20% y trombocitopenia en el 12% de los casos. La cifra media de linfocitos fue 62&#215;10 elevado a 9\/l (extremos: 6-475&#215;10 elevado a 9\/l).  la infiltracion medular fue superior al 80% en el 46% de los pacientes. Se efectuo biopsia medular a 97 pacientes, predominando el patron difuso (44%). Las alteraciones bioquimicas mas frecuentes fueron los incrementos de bun (55%), fosfatasa alcalina (42%) y ldh (38%). Se hallo hipogammaglobulinemia en el 55% siendo la hipo-igm la mas comun (66%). Se detecto una gammapatia monoclonal en el 4% de los casos. El tdl se calculo en 75 casos, siendo inferior a un a\u00f1o en el 32%. El 34% de los pacientes no requirio terapia antileucemica. Al cierre del analisis habian muerto 100 pacientes. La mediana de supervivencia fue de 57 meses. La muerte se relaciono con la llc en el 53% de los casos. El analisis univariante de factores pronosticos mostro el valor de variables clinicas (edad, sintomas, adenopatias, esplenomegalia, hepatomegalia, estadios clinicos), hematologicas (hemoglobina, plaquetas, leucocitos, linfocitos, infiltracion medular, patron de biopsia, linfocitos hendidos, prolinfocitos, tdl) y bioquimicas (bun, creatinina, calcio, fosforo, acido urico y albumina). El analisis multivariante selecciono la combinacion del estadio de rai, edad, adenopatias cervicales, albumina y bun. Al excluir los estadios clinicos, resultaron seleccionadas: infiltracion medular, albumina, adenopatias cervicales, edad, hemoglobina, fosforo y bun. El estudio de factores pronosticos en el estadio a de binet des<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Leucemia linfatica cronica: caracteristicas clinicas y estudio de factores pronosticos de supervivencia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Leucemia linfatica cronica: caracteristicas clinicas y estudio de factores pronosticos de supervivencia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isidro Jarque Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1990<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel \u00e1ngel Sanz Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Emilio Montserrat Costa <\/li>\n<li>Joaqu\u00edn D\u00edaz Mediavilla (vocal)<\/li>\n<li>Luis Hernandez Nieto (vocal)<\/li>\n<li>Vicente Alberola Candel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isidro Jarque Ramos Se revisan 187 casos de llc-b, no tratados previamente, diagnosticados de 1969 a 1988. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,218,139],"tags":[19797,265710,9598,9971,9706,11727],"class_list":["post-151303","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-hematologia","category-medicina-interna","tag-emilio-montserrat-costa","tag-isidro-jarque-ramos","tag-joaquin-diaz-mediavilla","tag-luis-hernandez-nieto","tag-miguel-angel-sanz-alonso","tag-vicente-alberola-candel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/151303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=151303"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/151303\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=151303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=151303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=151303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}