{"id":15142,"date":"2018-03-09T09:02:10","date_gmt":"2018-03-09T09:02:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-modulacion-de-la-actividad-transcripcional-del-factor-inducible-en-hipoxia-hif-1-por-el-factor-de-transcripcion-c-jun\/"},"modified":"2018-03-09T09:02:10","modified_gmt":"2018-03-09T09:02:10","slug":"estudio-de-la-modulacion-de-la-actividad-transcripcional-del-factor-inducible-en-hipoxia-hif-1-por-el-factor-de-transcripcion-c-jun","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-modulacion-de-la-actividad-transcripcional-del-factor-inducible-en-hipoxia-hif-1-por-el-factor-de-transcripcion-c-jun\/","title":{"rendered":"Estudio de la modulaci\u00f3n de la actividad transcripcional del factor inducible en hipoxia hif-1 por el factor de transcripci\u00f3n c-jun"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Arantzazu Alfranca Gonz\u00e1lez <\/strong><\/h2>\n<p>En condiciones de baja presi\u00f3n de ox\u00edgeno, las c\u00e9lulas ponen en marcha un programa adaptativo que lleva a la inducci\u00f3n de varios genes, que son regulados transcripcionalmente por el factor inducible en hipoxia hif-1. por otro lado, hay otros factores de transcripci\u00f3n que se unen a secuencias en cis de los promotores y modulan la inducci\u00f3n por hif-1 de algunos genes.  en este trabajo, mostramos que c-jun coopera funcionalmente con la actividad transcripcional de hif-1 en varios tipos celulares. Un dominante negativo de c-jun, que carece de su dominio de transactivaci\u00f3n, inhibe parcialmente la transcripci\u00f3n mediada por hif-1. Por otro lado, la prote\u00edna coactivadora p300 potencia la cooperaci\u00f3n funcional entre ambos factores. Este efecto cooperativo no se debe a un aumento de la cantidad de hif-1alfa nuclear, ni requiere la uni\u00f3n directa de c-jun a adn., C-jun y hif-1 se asocian in vivo, pero no in vitro, sugiriendo que esta interaci\u00f3n implica la participaci\u00f3n de prote\u00ednas adicionales y\/o una modificaci\u00f3n postraduccional de estos factores. En este contexto, la hipoxia induce la fosforilaci\u00f3n de c-jun por jnk en c\u00e9lulas endoteliales. Este proceso est\u00e1 implicado en su efecto cooperativo, ya que el bloqueo espec\u00edfico de la ruta de jnk, y la mutaci\u00f3n de c-jun en ser 63\/73 inhiben su cooperaci\u00f3n funcional con hif-1. La cooperaci\u00f3n funcional entre c-jun y hif-1 proporciona una nueva perspectiva de la regulaci\u00f3n de algunos genes como vegf, que es un factor clave en la angiog\u00e9nesis tumoral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la modulaci\u00f3n de la actividad transcripcional del factor inducible en hipoxia hif-1 por el factor de transcripci\u00f3n c-jun<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la modulaci\u00f3n de la actividad transcripcional del factor inducible en hipoxia hif-1 por el factor de transcripci\u00f3n c-jun <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Arantzazu Alfranca Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Ort\u00edz De Land\u00e1zuri Busca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>angel Corbi lopez (vocal)<\/li>\n<li>Juan  Miguel Redondo moya (vocal)<\/li>\n<li>Carlos Caba\u00f1as gutierrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arantzazu Alfranca Gonz\u00e1lez En condiciones de baja presi\u00f3n de ox\u00edgeno, las c\u00e9lulas ponen en marcha un programa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,160,115,8901,35,9,156,1601,17],"tags":[30066,48445,38437,14425,21737,4670],"class_list":["post-15142","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-bioquimica","category-bioquimica-molecular","category-carcinogenesis","category-ciencias-de-la-vida","category-ciencias-medicas","category-patologia","category-patologia-cardiovascular","category-quimica","tag-angel-corbi-lopez","tag-arantzazu-alfranca-gonzalez","tag-carlos-cabanas-gutierrez","tag-francisco-sanchez-madrid","tag-juan-miguel-redondo-moya","tag-manuel-ortiz-de-landazuri-busca"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15142"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15142\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}