{"id":15143,"date":"2018-03-09T09:02:10","date_gmt":"2018-03-09T09:02:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-polimorfismo-del-receptor-de-la-vitamina-d-y-del-colageno-i-alfa-1-sobre-la-densidad-mineral-osea-y-la-fractura-osteoporotica-en-mujeres-postmenopausicas\/"},"modified":"2018-03-09T09:02:10","modified_gmt":"2018-03-09T09:02:10","slug":"efecto-del-polimorfismo-del-receptor-de-la-vitamina-d-y-del-colageno-i-alfa-1-sobre-la-densidad-mineral-osea-y-la-fractura-osteoporotica-en-mujeres-postmenopausicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-del-polimorfismo-del-receptor-de-la-vitamina-d-y-del-colageno-i-alfa-1-sobre-la-densidad-mineral-osea-y-la-fractura-osteoporotica-en-mujeres-postmenopausicas\/","title":{"rendered":"Efecto del polimorfismo del receptor de la vitamina d y del col\u00e1geno i alfa 1 sobre la densidad mineral \u00f3sea y la fractura osteopor\u00f3tica en mujeres postmenop\u00e1usicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Bernad Pineda <\/strong><\/h2>\n<p>La asociaci\u00f3n entre diversos polimorfismos y la baja dmo y fractura osteopor\u00f3tico contin\u00faa siendo un tema controvertido. La preValencia de los polimorfismos del receptor de la vitamina d (vdr) y del gen del col\u00e1geno tipo i alfa 1 (colia1) y la posible influencia sobre la densidad mineral \u00f3sea (dmo), la preValencia de fracturas, los niveles de algunos marcadores bioqu\u00edmicos de remodelamiento \u00f3seo y hormonas calcitropas son aspectos importantes en el estudio de la osteoporosis y han sido los objetivos de este trabajo.  se determin\u00f3 el polimorfismo bsmi del vdr y sp1 del colia1 en 238 y 319, respectivamente en mujeres postmenop\u00e1usicas no-osteopor\u00f3ticas (no-o) y osteopor\u00f3ticas (o), de una consulta de reumatolog\u00eda de Madrid. El protocolo de estudio comprend\u00eda historia cl\u00ednica completa con identificaci\u00f3n de factores de riesgo, encuesta diet\u00e9tica, adem\u00e1s de metabolismo fosfoc\u00e1lcico en \u00e9poca de baja irradiaci\u00f3n solar, estudio radiol\u00f3gico y de la masa \u00f3sea por densitometr\u00eda dxa.  se observ\u00f3 que el 60% (no-o) y el 66% (o) ten\u00edan una insuficiente ingesta de calcio en la dieta y el 36,4%, unos niveles s\u00e9ricos bajos de vitamina d, independientemente del grupo asignado (mujeres no-o, o sin fractura y o con fractura).  la distribuci\u00f3n del polimorfismo del vdr fue: bb: 21,9%, bb: 44,1% y bb: 34%. Se observ\u00f3 una mayor frecuencia del alotipo de riesgo bb en las mujeres o (27,5%), respecto a las no-o (15,4%), de forma significativa (p&lt;0,05), adem\u00e1s de menor dmo de cadera en el grupo con el alotipo bb. no se observ\u00f3 asociaci\u00f3n entre los genotipos del vdr y la frecuencia de fracturas. La distribuci\u00f3n del polimorfismo del colia1 fue: gg: 49,2%, gt: 39,5% y tt: 11,3%. La comparaci\u00f3n de la distribuci\u00f3n del alotipo de riesgo (tt) entre las mujeres no-o y o, present\u00f3 diferencia significativa (p&lt;0,05), as\u00ed como tambi\u00e9n entre las mujeres o con y sin fracturas (p&lt;0,0001). la presencia conjunta de bb y tt se encontr\u00f3 e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del polimorfismo del receptor de la vitamina d y del col\u00e1geno i alfa 1 sobre la densidad mineral \u00f3sea y la fractura osteopor\u00f3tica en mujeres postmenop\u00e1usicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del polimorfismo del receptor de la vitamina d y del col\u00e1geno i alfa 1 sobre la densidad mineral \u00f3sea y la fractura osteopor\u00f3tica en mujeres postmenop\u00e1usicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Bernad Pineda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Mart\u00edn Mola<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Munuerva Martinez <\/li>\n<li>nuria Gay (vocal)<\/li>\n<li>Luis Carre\u00f1o p\u00e9rez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Bernad Pineda La asociaci\u00f3n entre diversos polimorfismos y la baja dmo y fractura osteopor\u00f3tico contin\u00faa siendo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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