{"id":151526,"date":"2026-01-12T16:33:44","date_gmt":"2026-01-12T16:33:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-complejos-de-pdii-y-ptii-como-antitumorales\/"},"modified":"2026-01-12T16:33:44","modified_gmt":"2026-01-12T16:33:44","slug":"nuevos-complejos-de-pdii-y-ptii-como-antitumorales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevos-complejos-de-pdii-y-ptii-como-antitumorales\/","title":{"rendered":"Nuevos complejos de pd(ii) y pt(ii) como antitumorales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Aragon Salgado <\/strong><\/h2>\n<p>El presente estudio la perseguido la determinacion de los mecanismos de interaccion entre drogas antitumorales con dna y su modificacion en presencia de iones metalicos, asi como tabien la sintesis y caracterizacion estructural de nuevos complejos antitumorales a partir de ligandos ampliamente utilizados en quimioterapia anticancerigena (bleomicina, mitramicina y cis-ddp) y de los iones pd(ii) y pt(ii), buscando, bien un aumento de la capacidad antitumoral del ligando de partida o bien una dismunucion de la toxicidad que este presenta frente a tejidos sanos del organismo. Han sido utilizadas las tenicas siguientes: difraccion de rayox x, espectrocospia rmn (195pt y 13c), espectroscopia rse, dicroismo circular (dc), fluorescencia, analisis termico (tg y dta), espectroscopia uv-vis y titulaciones potenciometricas.  la bleomicina forma complejos con pd(ii) y pt(ii). El poder de intercalacion del complejo blm.Pd(ii) entre las bases del dna, caracterizado por la razon (dna)\/(blm)=2, es superior al que se obtiene para complejos con otros iones (relacion (dna)\/(blm)=6.) Se ha demostrado que a ph fisiologico la interaccion mith-dna y mith-suv puede tener lugar en presencia de ciertos cationes capaces de neutralizar las repulsiones entre la carga negativa sobre la mith y sobre los grupos fostato del dna o los grupos cargados negativamente de las suv. La carga (gn+) y el radio (r) de los cationes resultan determinantes en su actividad mediadora en la interaccion mith dna y mith suv, resultando optima para n-2 y r=1.3 a.  los complejos de pt(ii) obtenidos en las reaccion de cis- (pt(nh3)2(h2o)2)2+ con creatinina son dimeros \u00abcabeza-cabeza\u00bb y \u00abcabeza-cola\u00bb identificados a partir de estudios 195pt rmn.  han sido resueltas las estructuras cristalinas de:  trans-pd(creat)2cl2.2h2o, cis-pt(creat)2i2.3h2o, trans-pt(creat)2cl2.2h2o (cariedad amarilla y amarillo-verdosa). En los cuatro complejos, los atomos centrales de pd y pt son tetracoordina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos complejos de pd(ii) y pt(ii) como antitumorales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos complejos de pd(ii) y pt(ii) como antitumorales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Aragon Salgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1990<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Mart\u00edn Gil<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Fidel Mato V\u00e1zquez <\/li>\n<li>F.g.c. Geraldes Carlos (vocal)<\/li>\n<li>Eugenio Coronado Miralles (vocal)<\/li>\n<li> Matos Beja Ana M. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Aragon Salgado El presente estudio la perseguido la determinacion de los mecanismos de interaccion entre drogas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,1027,156,12451],"tags":[28964,101474,8981,265923,265922,265924],"class_list":["post-151526","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-oncologia","category-patologia","category-valladolid","tag-eugenio-coronado-miralles","tag-f-g-c-geraldes-carlos","tag-fidel-mato-vazquez","tag-francisco-javier-martin-gil","tag-manuel-aragon-salgado","tag-matos-beja-ana-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/151526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=151526"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/151526\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=151526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=151526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=151526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}