{"id":15189,"date":"2018-03-09T09:02:14","date_gmt":"2018-03-09T09:02:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/iniciacion-de-la-replicacion-del-dna-en-arabidopsis-regulacion-de-los-componentes-cdc6-cdt1-y-orc1-del-complejo-pre-replicativo\/"},"modified":"2018-03-09T09:02:14","modified_gmt":"2018-03-09T09:02:14","slug":"iniciacion-de-la-replicacion-del-dna-en-arabidopsis-regulacion-de-los-componentes-cdc6-cdt1-y-orc1-del-complejo-pre-replicativo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/iniciacion-de-la-replicacion-del-dna-en-arabidopsis-regulacion-de-los-componentes-cdc6-cdt1-y-orc1-del-complejo-pre-replicativo\/","title":{"rendered":"Iniciaci\u00f3n de la replicaci\u00f3n del dna en arabidopsis: regulaci\u00f3n de los componentes  cdc6, cdt1 y orc1 del complejo pre-replicativo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Mar Castellano Moreno <\/strong><\/h2>\n<p>La iniciaci\u00f3n de la replicaci\u00f3n es un proceso muy controlado durante el cual se produce la formaci\u00f3n y consiguiente activaci\u00f3n de los complejos pre-replicativos. La formaci\u00f3n de dichos complejos pre-replicativos consiste en un ensamblaje secuencial y ordenado de las prote\u00ednas o macrocomplejos prote\u00edcos orc, cdc6, cdt1 y mcms al origen del replicaci\u00f3n, siendo este ensamblaje uno de los principales sistemas de control de la iniciaci\u00f3n de la replicaci\u00f3n.  a esta tesis doctoral hemos aislado y caracterizado los componentes cdc6, cdt1 y orc1 de arabidopsis thaliana, componentes que no hab\u00edan sido caracterizados hasta la fecha. Esta identificaci\u00f3n nos ha permitido estudiar los diferentes mecanismos que regulan la disponibilidad de dichas prote\u00ednas en plantas. Hemos encontrado que cada una de estos tres componentes posee dos isoformas codificadas por dos genes diferentes, pero s\u00f3lo en el caso de atcdc6, esta duplicaci\u00f3n g\u00e9nica se debe a una duplicaci\u00f3n cromos\u00f3mica. los datos que se presentan demuestran que atcdc6 est\u00e1 altamente regulada a nivel de transcripci\u00f3n, tanto durante el desarrollo como durante el ciclo celular. Atcdc6 tambi\u00e9n est\u00e1 regulada a nivel de fosforilaci\u00f3n ya que interacciona y se fosforila in vitro por complejos ciclina\/cdk. Adem\u00e1s, atcdc6 se degrada en extractos de arabidopsis por la ruta del proteosoma.  as\u00edmismo, atcdt1 tambi\u00e9n interacciona tanto in vitro como in vivo con complejos cdk\/ciclina y concretamente se fosforila in vitro por atcdc2a\/cycd2 y atcdc2\/cyca, sugiriendo que la regulaci\u00f3n de cdt1 por fosforilaci\u00f3n es dependiente de ciclo celular.  por su parte, atorc1 est\u00e1 sujeto a regulaci\u00f3n por transcripci\u00f3n tanto a lo largo del ciclo celular, poseyendo un pico de expresi\u00f3n al comienzo de la fase s, como durante el desarrollo. Es m\u00e1s, el uso de diferentes t\u00e9cnicas de detecci\u00f3n de transcripci\u00f3n, apuntan a que los dos genes que codifican atorc1 est\u00e1n sujetos a expresi\u00f3n diferencial,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Iniciaci\u00f3n de la replicaci\u00f3n del dna en arabidopsis: regulaci\u00f3n de los componentes  cdc6, cdt1 y orc1 del complejo pre-replicativo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Iniciaci\u00f3n de la replicaci\u00f3n del dna en arabidopsis: regulaci\u00f3n de los componentes  cdc6, cdt1 y orc1 del complejo pre-replicativo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Mar Castellano Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Crisanto Gutierrez Armenta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: montserrat Pages torrens <\/li>\n<li>Manuel Serrano marug\u00e1n (vocal)<\/li>\n<li>Andr\u00e9s avelino Bueno nu\u00f1ez (vocal)<\/li>\n<li>julio Salinas mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Mar Castellano Moreno La iniciaci\u00f3n de la replicaci\u00f3n es un proceso muy controlado durante el cual [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[48562,45238,8069,48561,41977,19692],"class_list":["post-15189","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-andres-avelino-bueno-nunez","tag-crisanto-gutierrez-armenta","tag-julio-salinas-munoz","tag-m-mar-castellano-moreno","tag-manuel-serrano-marugan","tag-montserrat-pages-torrens"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15189"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15189\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}