{"id":15200,"date":"2018-03-09T09:02:15","date_gmt":"2018-03-09T09:02:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-en-el-metabolismo-del-zinc-cobre-y-metalotioneina-en-la-diabetes-mellitus-tipo-2\/"},"modified":"2018-03-09T09:02:15","modified_gmt":"2018-03-09T09:02:15","slug":"alteraciones-en-el-metabolismo-del-zinc-cobre-y-metalotioneina-en-la-diabetes-mellitus-tipo-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-en-el-metabolismo-del-zinc-cobre-y-metalotioneina-en-la-diabetes-mellitus-tipo-2\/","title":{"rendered":"Alteraciones en el metabolismo del zinc, cobre y metalotioneina en la diabetes mellitus tipo 2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xavier Raga Luria <\/strong><\/h2>\n<p>Introduccion: el zinc (zn) y el cobre (cu) destacan por su importancia e implicaciones biologicas. Las metalotioneinas (mt) son unas proteinas estrechamente relacionadas con el zn, cu y metales traza en general. La hiperglucemia cronica en la diabetes mellitus tipo 2(dm2) puede causar alteraciones en el status de zn y cu y en consecuencia, en de la mt. Objetivo principal: 1. Valorar mt como indicador del status de zn y cu en la dm2. objetivos secundarios: 1. Determinar las concentraciones sericas, eritrocitarias y urinarias de zn, cu, cp y mt en los grupos control y dm2. Analizar las diferencias observadas entre el grupo control y el grupo dm2 en los mencionados parametros. 3. Analizar las relaciones entre los parametros sericos, urinarios y eritrocitarios en el grupo control, y en grupo dm2. Material y metodos: la poblacion control estaba compuesta por 210 individuos y la poblacion dm2 por 170. Se evalu\u00f3 el indice de masa corporal (imc) y los siguientes parametros metabolicos: glucemia basal, hba1c, zn y cu en suero, orina y hematies (espectroscopia de emision atomica de induccion por plasma), mt en suero, orina y hematies (r.I.A) y cp en suero (actividad oxidasa). resultados : 1. La zinquemia de los pacientes dm2 no presenta diferencias con la zinquemia de los individuos control [937,50 (125,00) vs 980,00(111,87)ng\/l, p=ns]. Los pacientes dm2 presentan unos valores mas elevados de concentracion eritrocitaria de zn [12,00(1,28) vs 13,23+- 1,70 ug\/g hb,p&lt;0,001] y de excrecion urinaria de zn [2310,00(830,00) vs 430,00(190,00) ug\/g creatinina, p&lt;0,001]. 2. Los pacientes dm2 presentan una crupremia [1124,71+-223,81 vs 877,00(173,00)ng\/ml, p&lt;0,001], una concentracion eritrocitaria de cu[1,77(0,62) vs y 3,59+-1,06 ug\/g hb, p&gt;0,001]y una excrecion urinaria de cu [58,50(25,00) vs80,65 +-28,64 ug\/g creatinina, p&lt;0,001] mayores que los individuos control 3. Los valores de la concentracion de mt en suero [37,20(17,82)vs 98,65 (45,70)<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones en el metabolismo del zinc, cobre y metalotioneina en la diabetes mellitus tipo 2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones en el metabolismo del zinc, cobre y metalotioneina en la diabetes mellitus tipo 2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xavier Raga Luria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Rovira i virgili<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Paternain Suberviola Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Mar\u00eda Llobet mallafr\u00e9 <\/li>\n<li> Vilanova navarro M\u00aa angels (vocal)<\/li>\n<li>joan Vendrell ortega (vocal)<\/li>\n<li>modest Sabate pi\u00f1ol (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xavier Raga Luria Introduccion: el zinc (zn) y el cobre (cu) destacan por su importancia e implicaciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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