{"id":1524,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/efecto-posantibiotico-leucocitario-efecto-p-a-l-e-estudio-con-cuatro-moleculas\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"efecto-posantibiotico-leucocitario-efecto-p-a-l-e-estudio-con-cuatro-moleculas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-posantibiotico-leucocitario-efecto-p-a-l-e-estudio-con-cuatro-moleculas\/","title":{"rendered":"Efecto posantibiotico leucocitario (efecto p.a.l.e.). estudio con cuatro moleculas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Martin Bajo <\/strong><\/h2>\n<p>Durante el tratamiento de infecciones bacterianas con antimicrobianos, se establece una importante interaccion entre la droga administrada y las defensas del huesped para erradicar la bacteria invasora. La actividad microbicida de los polimorfonucleares humanos se basa fundamentalmente en la fagocitosis y muerte intracelular de la bacteria, siendo estos dos mecanismos esenciales en la eliminacion de una infeccion. Se conoce mucho acerca de la accion de los antibioticos sobre los microorganismos y de los mecanismos involucrados en la opsonizacion, fagocitosis y muerte de la bacteria. Sin embargo, se sabe relativamente poco de si antibioticos especificos alteran el encuentro entre fagocitos y bacterias por modificacion de la superficie y otras propiedades de la bacteria (fenotipo).  la exposicion de bacterias a altos niveles de antibiotico durante breves periodos de tiempo, aumenta la susceptibilidad del microorganismo a estos mecanismos de defensa del huesped.  en nuestra tesis pretendemos analizar el aumento de susceptibilidad de bacterias pretratadas con antibioticos aminoglicosidos (isepamicina y netilmicina) y fluorquinolonas (ofloxacino y norfloxacino) a la actividad bactericida de polimorfonucleares tanto en presencia como en ausencia de suero. Las observaciones obtenidas podrian explicar la eficacia de un regimen determinado de antibiotico y servir como base para establecer la duracion de los intervalos entre dosis.  bibliografia:  1) pruul, h., wetherall, b. &Amp; mcdonald, p.J. In vitro killing of erythromycin-exposed group a streptococci by polimorfonuclear leukocytes.  european journal of clinical microbiology, 1986, 5, 405-410.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto posantibiotico leucocitario (efecto p.a.l.e.). estudio con cuatro moleculas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto posantibiotico leucocitario (efecto p.a.l.e.). estudio con cuatro moleculas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Martin Bajo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Prieto Prieto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jos\u00e9 Picazo De La Garza <\/li>\n<li>Manuel L\u00f3pez-brea Calvo (vocal)<\/li>\n<li>Fco. Soriano Garcia (vocal)<\/li>\n<li> Garcia De Los Rios Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Martin Bajo Durante el tratamiento de infecciones bacterianas con antimicrobianos, se establece una importante interaccion entre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,597],"tags":[6615,6616,3474,3475,5875,6614],"class_list":["post-1524","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-microbiologia-clinica","tag-fco-soriano-garcia","tag-garcia-de-los-rios-jose","tag-jose-prieto-prieto","tag-juan-jose-picazo-de-la-garza","tag-manuel-lopez-brea-calvo","tag-marta-martin-bajo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/1524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=1524"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/1524\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=1524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=1524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=1524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}