{"id":15242,"date":"2018-03-09T09:02:19","date_gmt":"2018-03-09T09:02:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-oligodesoxirribonucleotidos-que-contienen-5-azacitosina-y-8-aminopurinas\/"},"modified":"2018-03-09T09:02:19","modified_gmt":"2018-03-09T09:02:19","slug":"sa%c2%adntesis-de-oligodesoxirribonucleotidos-que-contienen-5-azacitosina-y-8-aminopurinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sa%c2%adntesis-de-oligodesoxirribonucleotidos-que-contienen-5-azacitosina-y-8-aminopurinas\/","title":{"rendered":"S\u00edntesis de oligodesoxirribonucle\u00f3tidos que contienen 5-azacitosina y 8-aminopurinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Caridad G\u00c1\u00bcimil Garc\u00eda Ram\u00f3n De La <\/strong><\/h2>\n<p>A ra\u00edz de la elucidaci\u00f3n estructural del adn en el a\u00f1o 1953, la s\u00edntesis de los \u00e1cidos nucleicos, como portadores de la informaci\u00f3n gen\u00e9tica, se ha convertido en un objetivo importante para los qu\u00edmicos org\u00e1nicos. Centrada en este campo, en la presente tesis doctoral se ha llevado a cabo la introducci\u00f3n de dos tipos diferentes de an\u00e1logos de las bases naturales en oligonucle\u00f3tidos sint\u00e9ticos. As\u00ed mismo se ha realizado el estudio que dicha modificaci\u00f3n provoca en las propiedades de hibridaci\u00f3n de los correspondientes oligonucle\u00f3tidos modificados.  el trabajo de investigaci\u00f3n realizado se puede dividir en dos partes fundamentales:  1,- obtenci\u00f3n del mon\u00f3mero protegido y funcionalizado para la incorporaci\u00f3n de 5-azacitosina a oligodesoxirribonucle\u00f3tidos.  2,- preparaci\u00f3n e incorporaci\u00f3n de 8-aminopurinas a oligodesoxirribonucle\u00f3tidos.  en cuanto a la primera parte, la 5-azacitosina, perteneciente a un grupo de bases modificadas, es el agente m\u00e1s potente para inhibir la acci\u00f3n de la metiltransferasas en las citidinas del adn (estos compuestos se han empleado en el tratamiento de lecucemias). Para conseguir este primer objetivo de la tesis, se han desarrollado las estrategias sint\u00e9ticas oportunas, que incluyen el empleo de grupos protectores desarrollados por el dr. Pfleiderer para la protecci\u00f3n de las bases duratne la s\u00edntesis de oligonucle\u00f3tidos.  en el desarrollo de la segunda parte del trabajo, se han realizado an\u00e1lisis te\u00f3ricos de simulaci\u00f3n molecular de triples h\u00e9lices de adn, que sugirieron que la introducci\u00f3n de un grupo aminio en la posici\u00f3n c-8 de las h\u00e9lices tipo d(a.T.T.), Facilitar\u00eda la formaci\u00f3n de un enlace por puente de hidr\u00f3geno adicional que traer\u00eda consigo un incremento de la estabiliad de la triple h\u00e9lice. As\u00ed pues, se han analizado la s\u00edntesis y propiedades estabilizadoras de triples h\u00e9lices de oligodesoxirribonucle\u00f3tidos que contienen tres an\u00e1logos no naturales de las pu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de oligodesoxirribonucle\u00f3tidos que contienen 5-azacitosina y 8-aminopurinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de oligodesoxirribonucle\u00f3tidos que contienen 5-azacitosina y 8-aminopurinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Caridad G\u00c1\u00bcimil Garc\u00eda Ram\u00f3n De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Nacional de educaci\u00f3n a distancia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ramon Eritja Casadell\u00c1\u00a0<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  De mendoza sanz javier <\/li>\n<li>amelia Garc\u00eda fraile (vocal)<\/li>\n<li>modesto Orozco l\u00f3pez (vocal)<\/li>\n<li>Mar\u00eda  Jos\u00e9 Camarasa rius (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Caridad G\u00c1\u00bcimil Garc\u00eda Ram\u00f3n De La A ra\u00edz de la elucidaci\u00f3n estructural del adn en el a\u00f1o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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