{"id":15264,"date":"2018-03-09T09:02:21","date_gmt":"2018-03-09T09:02:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estructura-del-coronavirus-de-la-gastroenteritis-porcina-transmisible-y-encapsidacion-de-su-genoma\/"},"modified":"2018-03-09T09:02:21","modified_gmt":"2018-03-09T09:02:21","slug":"estructura-del-coronavirus-de-la-gastroenteritis-porcina-transmisible-y-encapsidacion-de-su-genoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estructura-del-coronavirus-de-la-gastroenteritis-porcina-transmisible-y-encapsidacion-de-su-genoma\/","title":{"rendered":"Estructura del coronavirus de la gastroenteritis porcina transmisible y encapsidaci\u00f3n de su genoma"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Escors Murugarren <\/strong><\/h2>\n<p>El virus de la gastroenteritis porcina transmisible (tgev) es un miembro de la familia de los coronavirus y contiene un rna gen\u00f3mico de 28.5 kb unido a la prote\u00edna n, formando una nucleoc\u00e1psida helicoidal que a su vez se organiza en una c\u00e1psida interna esf\u00e9rica. La c\u00e1psida est\u00e1 envuelta por la membrana del virus en la que se encuentran la prote\u00edna s, que forma la pepl\u00f3meros del virus, la prote\u00edna e (de envuelta) y la prote\u00edna m (de membrana). En 1996 nuestro grupo identific\u00f3 una c\u00e1psida interna del virus, compuesta por el rna del virus y las prote\u00ednas estructurales n y m. Este resultado fue inesperado dado que la prote\u00edna m es una prote\u00edna integral de membrana, y con el objetivo de explicarlo se llev\u00f3 a cabo esta tesis doctoral. Durante la tesis se ha demostrado que existen dos poblaciones de mol\u00e9culas de prote\u00edna m en la envuelta del virus, atendiendo a la topolog\u00eda que adoptan. Dos tercios de las mol\u00e9culas adoptan una topolog\u00eda nexo-cendo, es decir, con el extremo amino de la prote\u00edna expuesto en la superficie del viri\u00f3n y el extremo carboxilo en el interior, y un tercio en topolog\u00eda nexo-ceno, con los extremos amino y carboxilo expuestos en la superficie del viri\u00f3n. Se demostr\u00f3n que el extremo carboxilo de la prote\u00edna nexo-cendo forma parte estructural de la c\u00e1psida interna, ya que interacciona con ella y estabiliza su estructura. Al eliminarse la prote\u00edna m de las c\u00e1psidas purificadas, estas se desensamblaron dando lugar a la nucleoc\u00e1psida helicoidal del virus. En cambio, la prote\u00edna m con topolog\u00eda nexo-cexo se pierde durante la disoluci\u00f3n de la envuelta del virus debido a que expone el extremo carboxilo en la superficie del viri\u00f3n. Adicionalmente se estudiaron las posibles modificaciones post-traduccionales de la prote\u00edna de la nucleoc\u00e1psida (n) en las distintas estructuras del virus. Se encontraron dos posibles fosforilaciones en la prote\u00edna n, una de ellas presente en todas las estructuras del v<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estructura del coronavirus de la gastroenteritis porcina transmisible y encapsidaci\u00f3n de su genoma<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estructura del coronavirus de la gastroenteritis porcina transmisible y encapsidaci\u00f3n de su genoma <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Escors Murugarren <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis EnJuan es Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Parra fernandez <\/li>\n<li>Jos\u00e9 Antonio Melero fondevilla (vocal)<\/li>\n<li>amelia Nieto martin (vocal)<\/li>\n<li>rosa Esteban caribano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Escors Murugarren El virus de la gastroenteritis porcina transmisible (tgev) es un miembro de la familia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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