{"id":15304,"date":"2018-03-09T09:02:24","date_gmt":"2018-03-09T09:02:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-protea%c2%adnas-snare-en-la-exocitosis-del-neutrofilo\/"},"modified":"2018-03-09T09:02:24","modified_gmt":"2018-03-09T09:02:24","slug":"papel-de-protea%c2%adnas-snare-en-la-exocitosis-del-neutrofilo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-protea%c2%adnas-snare-en-la-exocitosis-del-neutrofilo\/","title":{"rendered":"Papel de prote\u00ednas snare en la exocitosis del neutr\u00f3filo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bel\u00e9n Mart\u00edn Mart\u00edn <\/strong><\/h2>\n<p>El neutr\u00f3filo es una c\u00e9lula madura encargada de la defensa del organismo frente a la invasi\u00f3n de microorganismos pat\u00f3genos. Para poder realizar esta funci\u00f3n, en el neutr\u00f3filo debe de llevar a cabo la degranulaci\u00f3n de forma secuencial, en respuesta a un est\u00edmulo inflamatorio, de los 4 t\u00edpos distintos de gr\u00e1nulos que posee (ves\u00edculas secretoras, gr\u00e1nulos de gelatinasa, gr\u00e1nulos espec\u00edficos y gr\u00e1nulos azur\u00f3filos).  la maquinaria que regula esta jerarqu\u00eda en la secreci\u00f3n de los gr\u00e1nulos corresponde, bas\u00e1ndonos en los resultados obtenidos en este trabajo, a la hip\u00f3tesis snare planteada para la secrecci\u00f3n en otros sistemas celulares (c\u00e9lulas neuronales y no neuronales). Seg\u00f1un esta hip\u00f3tesis, la fusi\u00f3n entre membranas est\u00e1 mediada por la interacci\u00f3n entre prote\u00ednas, denominadas prote\u00ednas snare (sintaxinas, vamps y prote\u00ednas snap), que est\u00e1n asociadas a las membranas de los compartimentos que se van a fusionar.  los neutr\u00f3filos humanos maduros presentan varios componentes de estas prote\u00ednas snare, identificados mediante t\u00e9cnicas de rt-pcr, clonaje y secuenciaci\u00f3n. entre ellos se pude citar la expresi\u00f3n de sintaxina 1c, 3a, 3b, 4,5,6,7,9,11 y 16, vamp 1,2,3,4,5,7 y 8. Asi como la presencia de sinaptotagmina v, mienbro de la familia de sinaptotagminas caracterizadas por se sensores de calcio en los procesos exocit\u00f3ticos regulados.  la secreci\u00f3n de los gr\u00e1nulos espec\u00edficos (gr\u00e1nulos m\u00f3viles) tras la activaci\u00f3n del neutr\u00f3filo est\u00e1 regulada por interacciones entre prote\u00ednas snare. Una de estas interacciones se produce entre sintaxina 6 (asociada a la membrana plasm\u00e1tica) y snap-23 (asociada a la membrana de los gr\u00e1nulos espec\u00edficos). Otra de las interacciones se establece entre sintaxina 4 (asociada a la membrana plasm\u00e1tica del neutr\u00f3filo) y vamp-2 (asociada a la membrana de los gr\u00e1nulos espec\u00edficos). Las prote\u00ednas snare asociadas a la membrana de los gr\u00e1nulos m\u00f3viles est\u00e1n ausentes en los gr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de prote\u00ednas snare en la exocitosis del neutr\u00f3filo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de prote\u00ednas snare en la exocitosis del neutr\u00f3filo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bel\u00e9n Mart\u00edn Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Faustino Mollinedo Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan Blasi <\/li>\n<li>Carlos de la Lahoz navarro (vocal)<\/li>\n<li>atanasio Pandiella alonso (vocal)<\/li>\n<li>Alberto Gomez alonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bel\u00e9n Mart\u00edn Mart\u00edn El neutr\u00f3filo es una c\u00e9lula madura encargada de la defensa del organismo frente a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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