{"id":15348,"date":"2018-03-09T09:02:28","date_gmt":"2018-03-09T09:02:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/glomerulosclerosis-segmentaria-y-focal-en-el-modelo-de-la-rata-zucker-obese-aes-un-modelo-experimental-de-causa-plurimetabolica-importancia-de-las-celulas-podocitarias\/"},"modified":"2018-03-09T09:02:28","modified_gmt":"2018-03-09T09:02:28","slug":"glomerulosclerosis-segmentaria-y-focal-en-el-modelo-de-la-rata-zucker-obese-aes-un-modelo-experimental-de-causa-plurimetabolica-importancia-de-las-celulas-podocitarias","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/glomerulosclerosis-segmentaria-y-focal-en-el-modelo-de-la-rata-zucker-obese-aes-un-modelo-experimental-de-causa-plurimetabolica-importancia-de-las-celulas-podocitarias\/","title":{"rendered":"Glomerulosclerosis segmentaria y focal en el modelo de la rata zucker obese. \u00c2\u00bfes un modelo experimental de causa plurimetab\u00f3lica?. importancia de las c\u00e9lulas podocitarias"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sandra Blanco Cano <\/strong><\/h2>\n<p>Uno de los elementos que influyen en el desarrollo de la glomerulosclerosis es la alteraci\u00f3n de los l\u00edpidos que junto a factores de riesgo como la hiperglucemia, la hipertensi\u00f3n y la hiperinsulinemia modulan el curso o evoluci\u00f3n de \u00e9sta a lo largo del tiempo.  el objetivo de este trabajo consiste en elucidar los mecanismos patol\u00f3gicos que provocan el desarrollo de una glomerulosclerosis incipiente en un modelo experimental espont\u00e1neo de diabetes mellitus tipo ii, hiperlipidemia, obesidad, e insuficiencia renal: la rata zucker obesa a diferentes edades. Asimismo, intentamos averiguar el papel que tienen las alteraciones del metabolismo lip\u00eddico utilizando dos f\u00e1rmacos que est\u00e1n introducidos ampliamente en la cl\u00ednica.  uno de ellos es un inhibidor del enzima de conversi\u00f3n de la angiotensina ii, el quinapril f\u00e1rmaco que en estudios previos en nuestro laboratorio demostr\u00f3 que era capaz de reducir y\/o prevenir la nefropat\u00eda. El segundo f\u00e1rmaco que utilizamos fue la atorvastatina, inhibidor del enzima hidroxi-coenzima a reductasa, principal enzima implicado en la regulaci\u00f3n de la s\u00edntesis del colesterol.  para ello se estudiaron diferentes par\u00e1metros bioqu\u00edmicos, el \u00e1rea glomerular (estudios de morfometr\u00eda), el n\u00famero de lesiones glomerulares focales, la ultraestructura glomerular (microscop\u00eda electr\u00f3nica), la expresi\u00f3n de diferentes citocinas (rt-pcr-competitiva e hibridaci\u00f3n in situ), factores de transcripci\u00f3n (southwetern inmunohistoqu\u00edmico) y diferentes marcadores de lesi\u00f3n renal (estudios inmunohistoqu\u00edmicos) que pudieran ayudarnos a definir mejor el desarrollo de la glomerulosclerosis en la rata zucker obesa. Se utilizaron como controles negativos los homol\u00f3gos heterocigotos fa\/fa, que nos permitieron discernir si la causa de las lesiones observadas correspond\u00eda al colesterol y\/o al genotipo de las ratas zucker obese.  como conclusi\u00f3n general el presente estudio propone al colesterol como el factor me<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Glomerulosclerosis segmentaria y focal en el modelo de la rata zucker obese. \u00c2\u00bfes un modelo experimental de causa plurimetab\u00f3lica?. importancia de las c\u00e9lulas podocitarias<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Glomerulosclerosis segmentaria y focal en el modelo de la rata zucker obese. \u00c2\u00bfes un modelo experimental de causa plurimetab\u00f3lica?. importancia de las c\u00e9lulas podocitarias <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sandra Blanco Cano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Romero  Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: celestino Rey-joly barroso <\/li>\n<li>aurelio Ariza fern\u00e1ndez (vocal)<\/li>\n<li>Alberto Martinez vea (vocal)<\/li>\n<li>josep Mar\u00eda Griny\u00f3 boira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sandra Blanco Cano Uno de los elementos que influyen en el desarrollo de la glomerulosclerosis es la 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