{"id":15374,"date":"2018-03-09T09:02:31","date_gmt":"2018-03-09T09:02:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-tirosina-fosfatasa-shp-1-en-el-cancer-de-prostata-regulacion-por-somatostatina\/"},"modified":"2018-03-09T09:02:31","modified_gmt":"2018-03-09T09:02:31","slug":"la-tirosina-fosfatasa-shp-1-en-el-cancer-de-prostata-regulacion-por-somatostatina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-tirosina-fosfatasa-shp-1-en-el-cancer-de-prostata-regulacion-por-somatostatina\/","title":{"rendered":"La tirosina fosfatasa shp-1 en el c\u00e1ncer de pr\u00f3stata: regulaci\u00f3n por somatostatina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Dario Zapata Pedro <\/strong><\/h2>\n<p>El c\u00e1ncer de pr\u00f3stata es una de las principales patolog\u00edas en los varones occidentales y la segunda causa de muerte de c\u00e1ncer.  actualmente, debido al creciente incremento de la vida media de la poblaci\u00f3n, se esta transformando en un grave problema de salud p\u00fablica.  la propuesta es un \u00f3rgano regulado no solo por andr\u00f3genos, sino tambi\u00e9n, por los factores de crecimiento y neuropeptidos secretados por las c\u00e9lulas neuroendocrinas de la prostata. Dentro de estos neuropeptidos se encuentra la somatostatina (ss), un potente inhibidor de la proliferaci\u00f3n para una gran cantidad de tumores s\u00f3lidos y l\u00edneas celulares tumorales.  los ensayos cl\u00ednicos utilizando analogos de ss no han arrojado resultados concluyentes, probablemente porque se desconocen los mecanismos de acci\u00f3n a trav\u00e9s de los cuales act\u00faan la ss.  estudiando el papel de este peptido en la prostata, hemos encontrado que las c\u00e9lulas prost\u00e1ticas tumorales humanas pc3 y lncap presentan un bucle autorino para ss que inhibe la proliferaci\u00f3n de ambas lineas celulares. a trav\u00e9s de estudios de rt-pcr hemos descrito la presencia de arnm para ss y para los receptores sst2 y sst5.  adem\u00e1s, hemos demostrado la traducci\u00f3n de estos mensajeros a las proteinas correspondientes, a trav\u00e9s de t\u00e9cnicas de imunocitoqu\u00edmica e inmunoblot. el tratamiento de las c\u00e9lulas con un anticuerpo anti-ss aumenta la proliferaci\u00f3n celular lo cual demuestra la funcionalidad del bucle. Esto queda corroborado por la disminuci\u00f3n en el crecimiento de las c\u00e9lulas pc3 que provoca la transfecci\u00f3n de las mismas con un plasmido que permita la sobreexpresi\u00f3n transitoria de ss.  con la finalidad de investigar cuales eran los mecanismos moleculares a trav\u00e9s de los cuales actuaba el bucle aucotrino descrito, investigamos la presencia de la tirosina fosfatasa shp-1 en ambas l\u00edneas celulares. esta enzima se expresa tanto en pc3 como en lncap, siendo su nivel superior en lncap.  para ver que efe<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La tirosina fosfatasa shp-1 en el c\u00e1ncer de pr\u00f3stata: regulaci\u00f3n por somatostatina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La tirosina fosfatasa shp-1 en el c\u00e1ncer de pr\u00f3stata: regulaci\u00f3n por somatostatina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Dario Zapata Pedro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/01\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Bego\u00f1a Col\u00e1s Escudero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Prieto villap\u00fan <\/li>\n<li>Javier Angulo cuesta (vocal)<\/li>\n<li> L\u00f3pez de villaverde Jos\u00e9 ignacio (vocal)<\/li>\n<li> Santiesteban sanz Mar\u00eda pilar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dario Zapata Pedro El c\u00e1ncer de pr\u00f3stata es una de las principales patolog\u00edas en los varones occidentales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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