{"id":15380,"date":"2002-01-02T00:00:00","date_gmt":"2002-01-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-moleculares-de-inflamacion-en-la-isquemia-cerebral-aguda\/"},"modified":"2002-01-02T00:00:00","modified_gmt":"2002-01-02T00:00:00","slug":"marcadores-moleculares-de-inflamacion-en-la-isquemia-cerebral-aguda","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/marcadores-moleculares-de-inflamacion-en-la-isquemia-cerebral-aguda\/","title":{"rendered":"Marcadores moleculares de inflamaci\u00f3n en la isquemia cerebral aguda."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Purificaci\u00f3n Cacabelos P\u00e9rez <\/strong><\/h2>\n<p>Introducci\u00f3n  en las primeras horas tras el infarto cerebral algunos pacientes presentan un empeoramiento de sus s\u00edntomas neurol\u00f3gicos. Los mecanismos por los que se produce este deterioro neurol\u00f3gico precoz no se conocen con exactitud. tampoco disponemos en la actualidad de un marcador biol\u00f3gico eficaz que nos permita predecir esta progresi\u00f3n. Aunque se ha observado la liberaci\u00f3n de citocinas inflamatorias y mol\u00e9culas de adhesi\u00f3n intercelular precozmente tras la isquemia no se sabe si est\u00e1n implicadas en el deterioro neurol\u00f3gico precoz.  objetivos  determinar el perfil temporal de las concentraciones de citocinas y mol\u00e9culas de adhesi\u00f3n intercelular en pacientes durante la fase aguda del infarto cerebral para intentar establecer su papel en la fisiopatolog\u00eda del infarto y su posible relaci\u00f3n con la progresi\u00f3n del da\u00f1o neurol\u00f3gico.  material y m\u00e9todos  seleccionamos de foram prospectiva 271 pacientes con infarto cerebral de menos de 24 horas de evoluci\u00f3n en los que realizamos en el momento de la admisi\u00f3n y al cabo de 48 horas la determinaci\u00f3n en suero y l\u00edquido cefalorraqu\u00eddeo lcr de citocinas (il-4, il-6, il-10, fnt-a e if-y) y mol\u00e9culas de adhesi\u00f3n intercelular (icam-1 y vcam-1). Definimos infarto progresivo como aquel en el que se produce un empeoramiento de los s\u00edntomas en las primeras 48 horas que causa una disminuci\u00f3n en 1 \u00f3 m\u00e1s puntos en la escala canadiense sin tener en cuenta el \u00e1rea de la orientaci\u00f3n.  resultados  observamos que un 35,8% de los pacientes con infarto presentaron un deterioro neurol\u00f3gico precoz. Este grupo de pacientes presentaban de forma significativa en el momento de su admisi\u00f3n valores mayores en cuero y lcr de il-6 (suero: 35,16 vs 9,69, p 0,000; lcr:36,11 vs 3,7, 9 0,000), fnt-a (suero: 21,35 vs 14,85, p 0,000; lcr: 23,84 vs 9,74, p 0,000) y de icam-1 (sueros: 457,08 vs 262,21, p 0,04; lcr: 29,69 vs 16,35, p 0,012). Estas diferencias persit\u00edan igual de significativ<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores moleculares de inflamaci\u00f3n en la isquemia cerebral aguda.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores moleculares de inflamaci\u00f3n en la isquemia cerebral aguda. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Purificaci\u00f3n Cacabelos P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Castillo S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Noya  Garc\u00eda <\/li>\n<li>Jos\u00e9 \u00e1lvarez sab\u00edn (vocal)<\/li>\n<li>Manuel Mart\u00ednez p\u00e9rez (vocal)<\/li>\n<li>julio Fermoso garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Purificaci\u00f3n Cacabelos P\u00e9rez Introducci\u00f3n en las primeras horas tras el infarto cerebral algunos pacientes presentan un empeoramiento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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