{"id":15387,"date":"2002-01-02T00:00:00","date_gmt":"2002-01-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variacion-genetica-del-sistema-renina-angiotensina-oxido-nitrico-sintasa-endotelial-y-apolipoproteina-e-implicacion-en-la-enfermedad-coronaria\/"},"modified":"2002-01-02T00:00:00","modified_gmt":"2002-01-02T00:00:00","slug":"variacion-genetica-del-sistema-renina-angiotensina-oxido-nitrico-sintasa-endotelial-y-apolipoproteina-e-implicacion-en-la-enfermedad-coronaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/variacion-genetica-del-sistema-renina-angiotensina-oxido-nitrico-sintasa-endotelial-y-apolipoproteina-e-implicacion-en-la-enfermedad-coronaria\/","title":{"rendered":"Variacion genetica del sistema renina-angiotensina, oxido nitrico sintasa endotelial y apolipoproteina e: implicacion en la enfermedad coronaria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruth Alvarez Diaz <\/strong><\/h2>\n<p>La enfermedad coronaria es la principal causa de mortalidad en los paises desarrollados. Muchos procesos fisiopatologicos coronarios y vasculares se encuentran relacionados con la expresi\u00f3n diferencial de determinados genes. La presencia de variantes en la secuencia de estos genes (polimorfismos) determina una varibilidad interindividual que podria asociarse al grado de susceptibilidad al desarrollar la enfermedad.  el sistema renina-anginotensina (sra) desempe\u00f1a un papel fundamental en la homeostasis salina y en el mantenimiento del tono vascular. Este sistema est\u00e1 formado por diversos componentes, como enzimas proteol\u00edticos (eca, renina) y hormonas pept\u00eddicas (angiotensinas) que ejercen su funci\u00f3n a traves de la union  a los correspondientes receptores de membrana, de los cuales se han caracterizado dos en el hombre (at1 y at2). Algunos estudios han demostrado la implicacion de la variaci\u00f3n en los genes que codifican estos componentes en diversas enfermedades cardiovaculares. Otros, en cambio, no han encontrado tal asociaci\u00f3n.  el oxido nitrico (no) desempe\u00f1a importantes funciones en la pared vascular, como la inhibici\u00f3n de la agregaci\u00f3n plaquetaria y la adhesi\u00f3n monoc\u00edtica o la regulaci\u00f3n de la proliferacion de las celulas del musculo liso. El \u00f3xido nitrico es sintetizado por las oxido nitrico sintasas (nos) a partir del aminoacido l-arginina. El gen de la oxido nitrico sinitasa endotelial es polimorfico y se ha relacionado con el riesgo de desarrollar enfermedad coronaria e hipertensi\u00f3n.  tambien los genes que codifican apolipoproteinas se presentan como genes candidatos para los estudios geneticos de asociaci\u00f3n a enfermedad coronaria. la apolipoproteina e(apoe) forma parte de los remanentes de los quilomicrones, de la vldl y de las lipoproteinas de alta densidad (hdl), y es un ligando critico para la depuraci\u00f3n de estas sustancias. La apoe es una proteina polimorfica. La variaci\u00f3n genetica de este locus contribuy<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variacion genetica del sistema renina-angiotensina, oxido nitrico sintasa endotelial y apolipoproteina e: implicacion en la enfermedad coronaria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variacion genetica del sistema renina-angiotensina, oxido nitrico sintasa endotelial y apolipoproteina e: implicacion en la enfermedad coronaria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruth Alvarez Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eliecer Coto Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: llosa Arturo cortina <\/li>\n<li>cubells Luisa botella (vocal)<\/li>\n<li>suarez Francisco ortega (vocal)<\/li>\n<li> Enrique molinero de Miguel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruth Alvarez Diaz La enfermedad coronaria es la principal causa de mortalidad en los paises desarrollados. Muchos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,8846,17],"tags":[49106,25631,49108,49105,49104,49107],"class_list":["post-15387","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-oviedo","category-quimica","tag-cubells-luisa-botella","tag-eliecer-coto-garcia","tag-enrique-molinero-de-miguel","tag-llosa-arturo-cortina","tag-ruth-alvarez-diaz","tag-suarez-francisco-ortega"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15387"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15387\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15387"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15387"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}