{"id":154211,"date":"2026-01-12T17:10:39","date_gmt":"2026-01-12T17:10:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/penetracion-intraocular-de-ciclosporina-a-estudio-experimental\/"},"modified":"2026-01-12T17:10:39","modified_gmt":"2026-01-12T17:10:39","slug":"penetracion-intraocular-de-ciclosporina-a-estudio-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/penetracion-intraocular-de-ciclosporina-a-estudio-experimental\/","title":{"rendered":"Penetracion intraocular de ciclosporina a: estudio experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Bellot Bernabe Juan  Lorenzo <\/strong><\/h2>\n<p>La ciclosporina a (cya) es un inmunosupresor potente, que esta siendo usado tambien en oftalmolog\u00eda en la prevencion del rechazo inmunologico del transplante corneal y en patolog\u00edas oculares de patogenia inmune (como la uveitis endogena no infecciosa). Debido a los potenciales efectos toxicos que provoca la cya, cuando se rebasan determinados niveles sanguineos de la misma, otros autores han intentado encontrar una via topica para la administracion del farmaco, con el fin de lograr un mayor efecto terapeutico local (ocular), minimizando el riesgo de aparicion de efectos toxicos.  en la presente tesis, se estudian las concentraciones de la cya halladas en estructuras oculares (cornea, humor acuoso y vitreo) y en la sangre de conejos albinos sanos, tras la administracion de un colirio de cya al 2% en aceite de oliva, siguiendo distintas pautas de aplicacion. Se demuestra que los niveles de cya (medidos por radioinmunoensayo con anticuerpos monoclonales especificos), se acumulan de forma dosis-dependiente en la cornea del conejo y penetra escasamente en el ojo, siendo este hallazgo de importancia para el tratamiento, con la droga, de las patolog\u00edas antes mencionadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Penetracion intraocular de ciclosporina a: estudio experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Penetracion intraocular de ciclosporina a: estudio experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Bellot Bernabe Juan  Lorenzo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge  Luciano Ali\u00f3 Sanz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Justo Medrano Heredia <\/li>\n<li>Jaime Miralles De Imperial Mora Figueroa (vocal)<\/li>\n<li>Concepcion Navarro Segura (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bellot Bernabe Juan Lorenzo La ciclosporina a (cya) es un inmunosupresor potente, que esta siendo usado tambien [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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