{"id":154247,"date":"2026-01-12T17:10:51","date_gmt":"2026-01-12T17:10:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-estructural-de-la-arginasa-de-higado-de-rata-mediante-modificaciones-quimicas-y-estudios-inmunologicos\/"},"modified":"2026-01-12T17:10:51","modified_gmt":"2026-01-12T17:10:51","slug":"caracterizacion-estructural-de-la-arginasa-de-higado-de-rata-mediante-modificaciones-quimicas-y-estudios-inmunologicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-estructural-de-la-arginasa-de-higado-de-rata-mediante-modificaciones-quimicas-y-estudios-inmunologicos\/","title":{"rendered":"\u00abcaracterizacion estructural de la arginasa de higado de rata mediante modificaciones quimicas y estudios inmunologicos\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Amalia D\u00edez Mart\u00edn <\/strong><\/h2>\n<p>Se ha purificado la arginasa de higado de rata obteniendose una preparacion enzimatica muy estable, con dos bandas de proteina de pesos moleculares 39500 y 37000 respectivamente que se ponen de manifiesto mediante electroforesis en gel de poliacrilamida en condiciones desnaturalizantes. Los estudios inmunologicos que se llevan a cabo indican que ambas bandas son constitutivas de la celula, corresponden a arginasa y no son formas isoenzimaticas de la misma. La union de mn++ a la enzima provoca un cambio conformacional en la misma aumentando la estabilidad de la arginasa frente a la accion de agentes proteoliticos y desnaturalizantes. Los resultados del proceso proteolitco difieren en presencia y ausencia del cation.  en los estudios de inmovilizacion de la arginasa en un coagulo de fibrina, se observa que la enzima atrapada aumenta la estabilidad de la misma frente al tiempo, la temperatura y diversos agentes desnaturalizantes. Ademas a ph fisiologico la arginasa inmovilizada es mas estable que la soluble. Todo ello hace que este proceso de inmovilizacion presente una serie de ventajas para su uso en la terapia enzimatica del tratamiento de las hiperargininemias como de los tumores dependientes de arginina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abcaracterizacion estructural de la arginasa de higado de rata mediante modificaciones quimicas y estudios inmunologicos\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abcaracterizacion estructural de la arginasa de higado de rata mediante modificaciones quimicas y estudios inmunologicos\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Amalia D\u00edez Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Germ\u00e1n Soler  Grau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Ruiz Amil <\/li>\n<li>Carlos Guti\u00e9rrez Merino (vocal)<\/li>\n<li>Francisco Castillo Rodriguez (vocal)<\/li>\n<li>Gin\u00e9s Salido Ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amalia D\u00edez Mart\u00edn Se ha purificado la arginasa de higado de rata obteniendose una preparacion enzimatica muy [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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