{"id":154260,"date":"2026-01-12T17:10:58","date_gmt":"2026-01-12T17:10:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-posible-influencia-de-la-diabetes-rifampicina-y-cimetidina-en-el-fenotipo-metabolico-oxidativo-de-debrisoquina\/"},"modified":"2026-01-12T17:10:58","modified_gmt":"2026-01-12T17:10:58","slug":"estudio-de-la-posible-influencia-de-la-diabetes-rifampicina-y-cimetidina-en-el-fenotipo-metabolico-oxidativo-de-debrisoquina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-posible-influencia-de-la-diabetes-rifampicina-y-cimetidina-en-el-fenotipo-metabolico-oxidativo-de-debrisoquina\/","title":{"rendered":"Estudio de la posible influencia de la diabetes, rifampicina y cimetidina en el fenotipo metabolico oxidativo de debrisoquina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Lago Deibe <\/strong><\/h2>\n<p>Se estudia la influencia sobre el fenotipo metabolico oxidativo de debrisoquina ejercida por: i)+ cimetidina (inhibidor enzimatico) a 400 mgr\/8h durante 5 dias produce una ligera inhibicion del citocromo de debrisoquina en metabolizadores rapidos (mr) sin modificar el fenotipo. Ii)-rifampicina (inductor enzimatico) a 600 mgr\/dia durante 14 dias produce una ligera induccion del citocromo de debrisoquina tanto en mr como en metabolizadores lentos (ml) sin modificar el fenotipo de estos ultimos. Iii)-nuestra poblacion de diabeticos (145) presenta, respecto al fenotipo de debrisoquina, una distribucion polimorfica similar que los sanos con un 5,5% de ml ( 5,8% de ml en los sanos); los diabeticos tratados con hipoglucemiantes orales presentan un mayor porcentaje de metabolizadores intermedios que los sanos, cualquier factor a\u00f1adido al ser diabetico que se considere; los diabeticos no se diferencian de los sanos por sus indices metabolicos; la diabetes no parece alterar, ni su tratamiento, la capacidad metabolica del citocromo de debrisoquina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la posible influencia de la diabetes, rifampicina y cimetidina en el fenotipo metabolico oxidativo de debrisoquina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la posible influencia de la diabetes, rifampicina y cimetidina en el fenotipo metabolico oxidativo de debrisoquina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Lago Deibe <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Benitez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Maximo Bartolome Rodriguez <\/li>\n<li>Joaqu\u00edn Ingelmo Fern\u00e1ndez (vocal)<\/li>\n<li>Francisco Javier Galiana Martinez (vocal)<\/li>\n<li>Ascension Fernandez Gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Lago Deibe Se estudia la influencia sobre el fenotipo metabolico oxidativo de debrisoquina ejercida por: i)+ [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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