{"id":15445,"date":"2002-05-02T00:00:00","date_gmt":"2002-05-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-artrosis-precoz-mediante-resonancia-magnetica-de-alto-campo-microrradiologa%c2%ada-e-histologa%c2%ada\/"},"modified":"2002-05-02T00:00:00","modified_gmt":"2002-05-02T00:00:00","slug":"estudio-de-la-artrosis-precoz-mediante-resonancia-magnetica-de-alto-campo-microrradiologa%c2%ada-e-histologa%c2%ada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-artrosis-precoz-mediante-resonancia-magnetica-de-alto-campo-microrradiologa%c2%ada-e-histologa%c2%ada\/","title":{"rendered":"Estudio de la artrosis precoz mediante resonancia magn\u00e9tica de alto campo, microrradiolog\u00eda e histolog\u00eda"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Emilio Calvo Crespo <\/strong><\/h2>\n<p>Objetivo  estudiar los cambios precoces en el cart\u00edlago y el hueso subcondral en un modelo experimental de artrosis mediante resonancia magn\u00e9tica de alto campo, microrradiolog\u00eda e histolog\u00eda.  material y m\u00e9todos  se indujo una artrosis experimental por meniscectom\u00eda parcial medial en la rodilla de 24 conejos. Los resultados se compararon dos grupos control: 16 conejos a los que se les realiz\u00f3 una operaci\u00f3n simulada y 16 animales sanos. Las alteraciones precoces en el cart\u00edlago y el hueso subcondral se cuantificaron secuencialmente con un sistema experimental de resonancia magn\u00e9tica de alto campo a las 2,4,6,8 y 10 semanas despu\u00e9s de la intervenci\u00f3n. los cambios del hueso subcondral se midieron con histomorfometr\u00eda microradiogr\u00e1fica a las 6 y 10 semanas. Las articulaciones se valoraron macro y microsc\u00f3picamente y se correlacionaron con los resultados de las pruebas de imagen.  resultados  el estudio por resonancia magn\u00e9tica mostr\u00f3 un incremento en el grosor del cart\u00edlago en la zona articular de carga a las 4, 6 y 8 semanas en el f\u00e9mur y a las 6 semanas en la tibia. No se evidenciaron alteraciones \u00f3seas, ni en las im\u00e1genes de rm, ni en la histomorfometr\u00eda del hueso subcondral. a diferencia de las de dos controles, la meniscectom\u00eda desencaden\u00f3 alteraciones leves-palidez e irregularidades en la superficie del cart\u00edlago-. A partir de la sexta semana aparec\u00edan condrofitos en el borde medial de la superficie articular y ocasionalmente peque\u00f1as \u00falceras. Microsc\u00f3picamente se observaban cambios celulares y una reducci\u00f3n progresiva de la tinci\u00f3n de la matriz, expresi\u00f3n de una deplecci\u00f3n de proteoglicanos. Este \u00faltimo par\u00e1metro fue el que mejor se correlacion\u00f3 con la evoluci\u00f3n en el tiempo de la enfermedad y cronol\u00f3gicamente coincidi\u00f3 con el incremento en la altura del cart\u00edlago observado en el estudio por imagen. A las 52 semanas de la meniscectom\u00eda las alteraciones eran m\u00e1s severas, los osteofitos adqu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la artrosis precoz mediante resonancia magn\u00e9tica de alto campo, microrradiolog\u00eda e histolog\u00eda<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la artrosis precoz mediante resonancia magn\u00e9tica de alto campo, microrradiolog\u00eda e histolog\u00eda <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Emilio Calvo Crespo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>beaumont Cuenca Herrero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Munvera Martinez <\/li>\n<li> Rodr\u00edguez de la serena arturo (vocal)<\/li>\n<li>federico Manarro sanabr\u00eda (vocal)<\/li>\n<li>Alberto Jimenez ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Emilio Calvo Crespo Objetivo estudiar los cambios precoces en el cart\u00edlago y el hueso subcondral en un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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