{"id":15461,"date":"2002-06-02T00:00:00","date_gmt":"2002-06-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-sistema-endotelina-en-la-placa-ateromatosa-de-arteria-carotida-y-su-expresion-en-el-corazon-en-fallo\/"},"modified":"2002-06-02T00:00:00","modified_gmt":"2002-06-02T00:00:00","slug":"caracterizacion-del-sistema-endotelina-en-la-placa-ateromatosa-de-arteria-carotida-y-su-expresion-en-el-corazon-en-fallo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-del-sistema-endotelina-en-la-placa-ateromatosa-de-arteria-carotida-y-su-expresion-en-el-corazon-en-fallo\/","title":{"rendered":"Caracterizaci\u00f3n del sistema endotelina en la placa ateromatosa de arteria car\u00f3tida y su expresi\u00f3n en el coraz\u00f3n en fallo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Rosa Bernal L\u00f3pez <\/strong><\/h2>\n<p>La endotelina-1 (et-1) es un p\u00e9ptido con un potente efecto vasoconstrictor, mayor que el de cualquier otra sustancia hasta ahora conocida y podr\u00eda estar implicada en el desarrollo de complicaciones asociadas a la aterosclerosis en el sistema cardiovascular entre otros \u00f3rganos. La et-1 es capaz, adem\u00e1s de otras funciones, de inducir proliferaci\u00f3n celular y s\u00edntesis de prote\u00ednas de matriz en c\u00e9lulas de m\u00fasculo liso vascular, fibroblastos y cardimiocitos en cultivo, entre otro tipos celulares. Adem\u00e1s tiene efectos inotr\u00f3picos y cronotr\u00f3picos positivos en coraz\u00f3n aislado. Sin embargo, su implicaci\u00f3n en la fisiopatolog\u00eda cardiovascular no est\u00e1 clara. Nuestro objetivo global ha sido la caracterizaci\u00f3n del sistema endotelina en la placa ateromatosa de arteria car\u00f3tida y su expresi\u00f3n en el coraz\u00f3n en fallo. Los pacientes con aterosclerosis acelerada ten\u00edan, en conjunto, uno niveles plasm\u00e1ticos de et-1 superiores a los que presentaban los sujetos controles sanos. En la placa carot\u00eddea, existe gran cantidad de et-1, principalmente, en cmlv y \u00e1reas de infiltraci\u00f3n de macr\u00f3fagos, y un aumento significativo de los niveles de expresi\u00f3n del arnm de la ppet-1 y su receptor et a. En la aur\u00edcula izquierda, tanto de corazones de donantes sanos como de pacientes diagn\u00f3sticados de cardiomiopat\u00eda isqu\u00e9mica y sometidos a trasplante cardiaco, se encuentran los dos tipos de receptores de et-1, siendo m\u00e1s abundante el receptor et a que el receptor et b. En las aur\u00edculas de los pacientes existe un mayor n\u00famero de receptores totales, aunque se mantienen las proporciones de cada uno de \u00e9stos localiz\u00e1ndose en endocardio, miocardio y epicardio, siendo el miocardio la capa donde se concentra el mayor n\u00famero de ambos tipos de receptores. En resumen, nuestros resultados permiten ahondar en la funci\u00f3n del sistema et implicado en la fisiopatolog\u00eda de la aterosclerosis avanzada, demostrando que la et-1 es marcador de aterosclerosis y se re<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del sistema endotelina en la placa ateromatosa de arteria car\u00f3tida y su expresi\u00f3n en el coraz\u00f3n en fallo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del sistema endotelina en la placa ateromatosa de arteria car\u00f3tida y su expresi\u00f3n en el coraz\u00f3n en fallo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Rosa Bernal L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>cruz P\u00e9rez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Oya otero <\/li>\n<li>Manuel Rosety plaza (vocal)<\/li>\n<li>Jes\u00fas Egido de los rios (vocal)<\/li>\n<li>ram\u00f3n Pati\u00f1o barrios (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Rosa Bernal L\u00f3pez La endotelina-1 (et-1) es un p\u00e9ptido con un potente efecto vasoconstrictor, mayor que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,155,9,258,384,91,17],"tags":[49313,5119,49312,2097,1553,22636],"class_list":["post-15461","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-ciencias-clinicas","category-ciencias-medicas","category-hormonas","category-patologia-clinica","category-procesos-metabolicos","category-quimica","tag-cruz-perez-fernandez","tag-jesus-egido-de-los-rios","tag-m-rosa-bernal-lopez","tag-manuel-oya-otero","tag-manuel-rosety-plaza","tag-ramon-patino-barrios"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15461"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15461\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}