{"id":15468,"date":"2002-07-02T00:00:00","date_gmt":"2002-07-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-nuevos-sistemas-mucoadhesivos-de-quitosano-para-la-liberacion-especa%c2%adfica-de-moleculas-activas-a-traves-de-las-mucosas-gastrica-y-bucal\/"},"modified":"2002-07-02T00:00:00","modified_gmt":"2002-07-02T00:00:00","slug":"desarrollo-de-nuevos-sistemas-mucoadhesivos-de-quitosano-para-la-liberacion-especa%c2%adfica-de-moleculas-activas-a-traves-de-las-mucosas-gastrica-y-bucal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-de-nuevos-sistemas-mucoadhesivos-de-quitosano-para-la-liberacion-especa%c2%adfica-de-moleculas-activas-a-traves-de-las-mucosas-gastrica-y-bucal\/","title":{"rendered":"Desarrollo de nuevos sistemas mucoadhesivos de quitosano para la liberaci\u00f3n espec\u00edfica de mol\u00e9culas activas a trav\u00e9s de las mucosas g\u00e1strica y bucal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Portero Capdevila <\/strong><\/h2>\n<p>El objetivo principal de esta memoria ha sido investigar la utilidad y comportamiento del polisac\u00e1rido quitosano en el desarrollo de sistemas mucoadhesivos destinados a la administraci\u00f3n de mol\u00e9culas activas a nivel de las mucosas g\u00e1strica y bucal. Para ello, se han dise\u00f1ado dos tipos de sistemas de liberaci\u00f3n, microsferas mucoadhesivas y dispositivos mucoadhesivos bucales. Con relaci\u00f3n a las microsferas mucoadhesivas de quitosano, se ha investigado la utilidad de un proceso de reacetilaci\u00f3n superficial para controlar la solubilidad de las mismas en medio \u00e1cido y al mismo tiempo la cesi\u00f3n in vitro de los principios activos incorporados. Nuestro objetivo es que estas part\u00edculas liberen, los f\u00e1rmacos contenidos espec\u00edficamente en la mucosa g\u00e1strica. Los resultados obtendios demuestran que las microsferas reacetiladas con capaces de controlar la liberaci\u00f3n de los f\u00e1rmacos contenidos a consecuencia del descenso del contendio en grupos  amino libres del quitosano, y que mediante la apropiada selecci\u00f3n del tiempo de reacetilaci\u00f3n, tipo de sal y peso molecular del quitosano utilizado se puede modular la iberaci\u00f3n de los f\u00e1rmacos al mismo tiempo que conservan su actividad antimicrobiana. adem\u00e1s, dichas microsferasse adhiren a la capa de mucus e incluso difunden a trav\u00e9s de ella hasta localizarse en la mucosa g\u00e1strica de los ratones tras su  administraci\u00f3n in vivo. Estos resultados evidencian el gran potencial de estas nuevas microsferas de quitosano para su utilizaci\u00f3n en el tratamiento de las ulceras g\u00e1stricas consecuencia de la infecci\u00f3n de la mucosa g\u00e1strica por parte del microorganismo helicobacter pylori.  adem\u00e1s, hemos dise\u00f1ado tres nuevos dispositivos bicapa mucoadhesivos adecuados para la administraci\u00f3n bucal de mol\u00e9culas terap\u00e9uticas de bajo (nifedipina y propranolol) y elevado (insulina) peso molecular. Los resultados experimentales demostraron que mediante la selecci\u00f3n adecuada de las variables de for<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de nuevos sistemas mucoadhesivos de quitosano para la liberaci\u00f3n espec\u00edfica de mol\u00e9culas activas a trav\u00e9s de las mucosas g\u00e1strica y bucal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de nuevos sistemas mucoadhesivos de quitosano para la liberaci\u00f3n espec\u00edfica de mol\u00e9culas activas a trav\u00e9s de las mucosas g\u00e1strica y bucal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Portero Capdevila <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Remu\u00f1\u00e1n L\u00f3pez M. Carmen<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Vila jato <\/li>\n<li>alicia Rodriguez gascon (vocal)<\/li>\n<li> Bermejo sanz Mar\u00eda del val (vocal)<\/li>\n<li>\u00e1ngeles Mar\u00eda Heras caballero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Portero Capdevila El objetivo principal de esta memoria ha sido investigar la utilidad y comportamiento del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,3304,977],"tags":[43248,49330,4016,49332,3220,49331],"class_list":["post-15468","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-preparacion-de-farmacos","category-santiago-de-compostela","tag-alicia-rodriguez-gascon","tag-ana-portero-capdevila","tag-angeles-maria-heras-caballero","tag-bermejo-sanz-maria-del-val","tag-jose-luis-vila-jato","tag-remunan-lopez-m-carmen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15468"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15468\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}