{"id":154885,"date":"2026-01-12T17:15:08","date_gmt":"2026-01-12T17:15:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/complejos-de-inclusion-con-ciclodextrinas-como-sistemas-para-mejorar-las-caracteristicas-biofarmaceuticas-del-naproxen\/"},"modified":"2026-01-12T17:15:08","modified_gmt":"2026-01-12T17:15:08","slug":"complejos-de-inclusion-con-ciclodextrinas-como-sistemas-para-mejorar-las-caracteristicas-biofarmaceuticas-del-naproxen","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/complejos-de-inclusion-con-ciclodextrinas-como-sistemas-para-mejorar-las-caracteristicas-biofarmaceuticas-del-naproxen\/","title":{"rendered":"Complejos de inclusion con ciclodextrinas como sistemas para mejorar las caracteristicas biofarmaceuticas del naproxen."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Otero Espinar Francisco Jose <\/strong><\/h2>\n<p>Se presenta una revision detallada de las estructuras y propiedades de las ciclodextrinas, asi como su habilidad para formar complejos de inclision de medicamentos haciendo referencia al interes biofarmaceutico de los mismos. El trabajo experimental se centro en la encapsulacion de una molcecula antiinflamatoria; el naproxen, con el objeto de reducir la irritacion gastrica de que son responsables estos antiinflamatorios. Para la elaboracion de las formulaciones se utilizaron diversas variedades de ciclodextrinas, a diferentes concentraciones y haciendo uso de tecnicas como la liofilizacion, atomizacion y amasado. La determinacion de las constantes de estabilidad y de los perfiles de liberacion del naproxen permitio seleccionar la formulacion de beta-ciclodextrina preparada por liofilizacion, para la realizacion de los ensayos in vivo. El estudio de biodisponibilidad en humanos no permitio detertar diferencias significativas entre la formulacion desarrollada y una solucion de naproxen. No obstante, una notable reduccion de la irritacion gastrica de este medicamento, fue evidenciada tras la administracion oral de la formulacion citada en ratas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Complejos de inclusion con ciclodextrinas como sistemas para mejorar las caracteristicas biofarmaceuticas del naproxen.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Complejos de inclusion con ciclodextrinas como sistemas para mejorar las caracteristicas biofarmaceuticas del naproxen. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Otero Espinar Francisco Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Vila Jato<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jose Mi\u00f1ones Trillo <\/li>\n<li>Victor Jimenez Torres (vocal)<\/li>\n<li>Ram\u00f3n Mart\u00ednez Pacheco (vocal)<\/li>\n<li> Garcia Sanchez M. Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Otero Espinar Francisco Jose Se presenta una revision detallada de las estructuras y propiedades de las ciclodextrinas, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,977],"tags":[3756,3220,2621,268972,3307,3309],"class_list":["post-154885","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-santiago-de-compostela","tag-garcia-sanchez-m-jose","tag-jose-luis-vila-jato","tag-jose-minones-trillo","tag-otero-espinar-francisco-jose","tag-ramon-Martinez-pacheco","tag-victor-jimenez-torres"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/154885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=154885"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/154885\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=154885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=154885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=154885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}