{"id":154901,"date":"2026-01-12T17:15:16","date_gmt":"2026-01-12T17:15:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/elaboracion-de-comprimidos-de-cesion-sostenida-de-nifedipina-con-gelucire-estudio-tecnologico-y-biofarmaceutico\/"},"modified":"2026-01-12T17:15:16","modified_gmt":"2026-01-12T17:15:16","slug":"elaboracion-de-comprimidos-de-cesion-sostenida-de-nifedipina-con-gelucire-estudio-tecnologico-y-biofarmaceutico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/elaboracion-de-comprimidos-de-cesion-sostenida-de-nifedipina-con-gelucire-estudio-tecnologico-y-biofarmaceutico\/","title":{"rendered":"Elaboracion de comprimidos de cesion sostenida de nifedipina con gelucire. estudio tecnologico y biofarmaceutico."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Remu\u00f1an Lopez M. Carmen <\/strong><\/h2>\n<p>La puesta a punto de una formulacion resumen de nifedipina que de lugar a niveles prolongados en plasma a la vez que a una adecuada biodisponibilidad se plantea como una necesidad debido a la rapida eliminacion que experimenta del organismo asi como al importante efecto de primer paso a que se encuentra sometida y su baja solubilidad en agua. Este es precisamente el objetivo de la presente memoria. La parte experimental de la misma ha sido estructurada en tres secciones que corresponden a:  elaboracion de las formulaciones y estudio in vitro de las mismas (i), estudio del comportamiento in vivo de las formulaciones seleccionadas en base a los resultados obtenidos in vitro (ii) y estudio acelerado de estabilidad (iii). La distinta dependencia observada para los parametros caracteristicos de las curvas de disolucion respecto de las variables ensayadas abria grandes posibilidades en cuanto al control del perfil de disolucion de la nifedipina con los gelucire, que fueron posteriormente ratificadas mediante estudios in vivo.  este estudio demostro que las formulaciones experimentales presentan una biodisponibilidad similar a la de la formulacion de referencia siendo la velocidad de absorcion mas lenta de acuerdo con los valores del tiempo maximo.  por ultimo, las formulaciones elaboradas deben de ser protegidas de la humedad al ser almacenadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Elaboracion de comprimidos de cesion sostenida de nifedipina con gelucire. estudio tecnologico y biofarmaceutico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Elaboracion de comprimidos de cesion sostenida de nifedipina con gelucire. estudio tecnologico y biofarmaceutico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Remu\u00f1an Lopez M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Vila Jato<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Matias A. Llabres Martinez <\/li>\n<li>Angel Concheiro Nine (vocal)<\/li>\n<li>Ram\u00f3n Mart\u00ednez Pacheco (vocal)<\/li>\n<li>Eduardo Mari\u00f1o Hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Remu\u00f1an Lopez M. Carmen La puesta a punto de una formulacion resumen de nifedipina que de lugar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,9,189,957,3304,977],"tags":[3014,4078,3220,26005,3307,49331],"class_list":["post-154901","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-preparacion-de-farmacos","category-santiago-de-compostela","tag-angel-concheiro-nine","tag-eduardo-marino-hernandez","tag-jose-luis-vila-jato","tag-matias-a-llabres-Martinez","tag-ramon-Martinez-pacheco","tag-remunan-lopez-m-carmen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/154901","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=154901"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/154901\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=154901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=154901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=154901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}