{"id":155033,"date":"2026-01-12T17:16:29","date_gmt":"2026-01-12T17:16:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/quimioterapia-experimental-en-leishmaniosis-con-complejos-metalicos-de-nueva-sintesis\/"},"modified":"2026-01-12T17:16:29","modified_gmt":"2026-01-12T17:16:29","slug":"quimioterapia-experimental-en-leishmaniosis-con-complejos-metalicos-de-nueva-sintesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/quimioterapia-experimental-en-leishmaniosis-con-complejos-metalicos-de-nueva-sintesis\/","title":{"rendered":"\u00abquimioterapia experimental en leishmaniosis con complejos metalicos de nueva sintesis\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mesa Valle Mar\u00eda  Concepcion <\/strong><\/h2>\n<p>En la presente tesis doctoral se ha intentado encontrar una posible quimioterapia alternativa en el tratamiento de la leishmaniosis visceral o kala-azar en el hombre, enfermedad producida por el parasito leishmania donovani.  las experiencias llevadas a cabo han sido las siguientes:  1.- En primer lugar se evaluo la accion de 81 complejos metalicos de nueva sintesis frente a formas promastigotes del parasito \u00abin vitro\u00bb, comprobandose la accion de cada compuesto a diferentes dosis y tiempos de tratamiento.  2.- A continuacion y tras seleccionar aquellos complejos metalicos mas activos se procedio a ensayar la citotoxicidad de estos frente a la linea celular de macrofagos j 774.  3.- posteriormente, y con objeto de dilucidar un posible mecanismo de accion de los complejos anteriores se evaluo la accion que ejercian sobre la incorporacion de precursores radiactivos: timidina, uridina y leucina h3, pudiendo comprobar asi su accion sobre la sintesis de dna, rna o sintesis de proteinas respectivamente.  4.- Tras realizar las experiencias anteriores seleccionamos 5 complejos metalicos, cada uno con una estructura general, con una alta actividad in vitro y no citotoxicos y estudiamos el efecto ultraestructural ejercido sobre los parasitos.  5.- Por ultimo se llevaron a cabo los ensayos in vivo con los mismos complejos anteriores.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abquimioterapia experimental en leishmaniosis con complejos metalicos de nueva sintesis\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abquimioterapia experimental en leishmaniosis con complejos metalicos de nueva sintesis\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mesa Valle Mar\u00eda  Concepcion <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Osuna Carrillo De Albornoz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Salvador Gonz\u00e1lez Garc\u00eda <\/li>\n<li>Juan Oca\u00f1a Sierra (vocal)<\/li>\n<li>Jacques Barbe (vocal)<\/li>\n<li>Antonio Tovar Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mesa Valle Mar\u00eda Concepcion En la presente tesis doctoral se ha intentado encontrar una posible quimioterapia alternativa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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