{"id":15504,"date":"2002-08-02T00:00:00","date_gmt":"2002-08-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-de-la-eficacia-in-vivo-y-actividad-in-vitro-de-carbapenemes-en-un-modelo-de-neumona%c2%ada-experimental-por-acinetobacter-baumannii-multirresistente\/"},"modified":"2002-08-02T00:00:00","modified_gmt":"2002-08-02T00:00:00","slug":"evaluacion-de-la-eficacia-in-vivo-y-actividad-in-vitro-de-carbapenemes-en-un-modelo-de-neumona%c2%ada-experimental-por-acinetobacter-baumannii-multirresistente","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/evaluacion-de-la-eficacia-in-vivo-y-actividad-in-vitro-de-carbapenemes-en-un-modelo-de-neumona%c2%ada-experimental-por-acinetobacter-baumannii-multirresistente\/","title":{"rendered":"Evaluaci\u00f3n de la eficacia in vivo y actividad in vitro de carbapenemes en un modelo de neumon\u00edaexperimental por acinetobacter baumannii multirresistente"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Maximo Bernabeu Wittel <\/strong><\/h2>\n<p>La especie acinetobacter baumnannii constituye actualmente un pat\u00f3geno nosocomial emergente, siendo la neumon\u00eda la infecci\u00f3n que causa con m\u00e1s frecuencia. Por el desarrollo progresivo del multirresistencia de esta bacteria a diferentes antimicrobianos, el tratamiento de estas infecciones constituye actualmente un reto para el cl\u00ednico. En el presente trabajo se ha desarrollado un nuevo modelo de neumon\u00eda experimental por dos cepas de a. Baumannii multirresistente (una sensible y otra resistente a carbapenemes) en cobayas inmunocompetentes con el objetivo de evaluar la eficacia terap\u00e9utica y actividad in vitro de imipenem (imp) y meropenem (mrp) en monoterapia \u00f3 combinados con amikacina (ak).  en los estudios in vitro imipenem mostr\u00f3 mayor actividad bactericida que meropenem frente a la cepa sensible, mientras que frente a la cepa resistente \u00e9sta fue similar para ambos. Con respecto a la sinergia, las t\u00e9cnicas de tableros de ajedrez y curvas de tiempo muerte tuvieron una concordancia en el 50% de los experimentos. Globalmente considerado, la combinaci\u00f3n meropenem-amikacina mostr\u00f3 una mayor sinergia que imipenem-amikacina.  se evidenci\u00f3 una interacci\u00f3n farmacocin\u00e9tica significativa entre ambos carbapenemes y amikacina al administrarlos conjuntamente, que consisti\u00f3 en un descenso de la cmax, t1\/2 y auc de los carbapenemes, y de la cmax de amikacina. El mecanismo responsable m\u00e1s plausible lo constituir\u00eda la inactivaci\u00f3n qu\u00edmica molecular entre ambos f\u00e1rmacos in vivo.  los tratamientos con imipenem y la combinaci\u00f3n imipenem-amikacina fueron los m\u00e1s eficaces en la esterilizaci\u00f3n de hemocultivos de los grupos terap\u00e9uticos de 72 y 24 horas. Los resultados obtenidos con el aclaramiento bacteriano pulmonar fueron similares y concordantes con la esterilizaci\u00f3n de hemocultivos. el r\u00e9gimen m\u00e1s eficaz en los animales inoculados con la cepa sensible fue imipenem; en los inoculados con la cepa resistente lo fue amikacina. Se<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluaci\u00f3n de la eficacia in vivo y actividad in vitro de carbapenemes en un modelo de neumon\u00edaexperimental por acinetobacter baumannii multirresistente<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluaci\u00f3n de la eficacia in vivo y actividad in vitro de carbapenemes en un modelo de neumon\u00edaexperimental por acinetobacter baumannii multirresistente <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Maximo Bernabeu Wittel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jer\u00f3nimo Pachon D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez guijo <\/li>\n<li> Cordero mat\u00eda Mar\u00eda elisa (vocal)<\/li>\n<li> Muniain ezcurra Miguel angel (vocal)<\/li>\n<li>Javier Aznar martin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Maximo Bernabeu Wittel La especie acinetobacter baumnannii constituye actualmente un pat\u00f3geno nosocomial emergente, siendo la neumon\u00eda la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1085,69,139,10715],"tags":[49421,1660,2068,49420,10863,1935],"class_list":["post-15504","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-enfermedades-infecciosas","category-enfermedades-pulmonares","category-medicina-interna","category-sevilla","tag-cordero-matia-maria-elisa","tag-javier-aznar-martin","tag-jeronimo-pachon-diaz","tag-maximo-bernabeu-wittel","tag-muniain-ezcurra-miguel-angel","tag-pedro-sanchez-guijo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15504"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15504\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}