{"id":155113,"date":"2026-01-12T17:17:09","date_gmt":"2026-01-12T17:17:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-enzimas-de-la-via-biosintetica-de-cefamicina-c-en-nocardia-lactamdurans-lc411-y-en-variantes-amy\/"},"modified":"2026-01-12T17:17:09","modified_gmt":"2026-01-12T17:17:09","slug":"estudio-de-enzimas-de-la-via-biosintetica-de-cefamicina-c-en-nocardia-lactamdurans-lc411-y-en-variantes-amy","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-enzimas-de-la-via-biosintetica-de-cefamicina-c-en-nocardia-lactamdurans-lc411-y-en-variantes-amy\/","title":{"rendered":"\u00abestudio de enzimas de la via biosintetica de cefamicina c en nocardia lactamdurans lc411 y en variantes amy\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leonila Laiz Trobajo <\/strong><\/h2>\n<p>La biosintesis de cefamicina c por nocardia lactamdurans tiene lugar a traves de una via biosintetica que se inicia con la formacion del tripeptido (l-alfa-aminoadipil) &#8211; l-cisteinil-dvalina (acv) por la enzima acv sintetasa, seguida de la ciclacion de este tripeptido a isopenicilina n por la isopenicilina n sintasa (ipns). A continuacion, la isopenicilina n epimerasa (ipne) convierte isopenicilina n a penicilina n. Esta ultima enzima es muy labil. La ipns de n.  lactamdurans es un monomero, ya que el peso molecular de la forma no desnaturalizada de la enzima, calculado por filtracion en gel es identico al determinado por sds-page: 37500 da. Su punto isoelectrico es 5.5 la ipne de n. Lactamdurans fue purificada 93.2 veces. Es estabilizada por fosfato de piridoxal y tiene un peso molecular calculado por filtracion en gel de 59000. Una banda proteica de 59000 da. Y pi 5.1 &#8211; 5.26, se enriquece en fracciones activas analizadas en sds-page. Por otra parte, n. Lactamdurans var. Amy-, una cepa que no produce cefamicina c, posee ipns e ipne antigenicamente similares a las de la cepa amy+ , proteinas que se visualizan en electroforesis bidimensional.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abestudio de enzimas de la via biosintetica de cefamicina c en nocardia lactamdurans lc411 y en variantes amy\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abestudio de enzimas de la via biosintetica de cefamicina c en nocardia lactamdurans lc411 y en variantes amy\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leonila Laiz Trobajo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Francisco Mart\u00edn Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Fernando Laborda <\/li>\n<li>Juan Mesas Mesas (vocal)<\/li>\n<li>Jes\u00fas Sanchez (vocal)<\/li>\n<li>Jos\u00e9 Antonio Gil Santos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leonila Laiz Trobajo La biosintesis de cefamicina c por nocardia lactamdurans tiene lugar a traves de una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,35,955,4430,278,17],"tags":[2554,269159,4501,4494,4502,269158],"class_list":["post-155113","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-ciencias-de-la-vida","category-enzimologia","category-leon","category-microbiologia","category-quimica","tag-fernando-laborda","tag-jesus-sanchez","tag-jose-antonio-gil-santos","tag-juan-francisco-martin-martin","tag-juan-mesas-mesas","tag-leonila-laiz-trobajo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=155113"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155113\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=155113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=155113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=155113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}