{"id":155133,"date":"2026-01-12T17:17:15","date_gmt":"2026-01-12T17:17:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-la-concentracion-plasmatica-y-salivar-de-salicilato-en-ninos-con-artritis-cronica-juvenil-mediante-cromatografia-liquida-de-alta-resolucion\/"},"modified":"2026-01-12T17:17:15","modified_gmt":"2026-01-12T17:17:15","slug":"determinacion-de-la-concentracion-plasmatica-y-salivar-de-salicilato-en-ninos-con-artritis-cronica-juvenil-mediante-cromatografia-liquida-de-alta-resolucion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/determinacion-de-la-concentracion-plasmatica-y-salivar-de-salicilato-en-ninos-con-artritis-cronica-juvenil-mediante-cromatografia-liquida-de-alta-resolucion\/","title":{"rendered":"Determinacion de la concentracion plasmatica y salivar de salicilato, en ni\u00f1os con artritis cronica juvenil, mediante cromatografia liquida de alta resolucion."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elia Acitores Suz <\/strong><\/h2>\n<p>Para evitar las repetidas venopunciones practicadas a los pacientes con artritis cronica juvenil, en tratamiento con salicilatos, para ajustar la dosificacion de los mismos, se estudio la posibilidad de determinar la concentracion plasmatica de salicilato total (cpast) a traves de la determinacion de la concentracion salivar de acido salicilico (csas). Para ello se desarrollo un metodo de cromatografia liquida de alta resolucion, con el fin de determinar ambas concentraciones en 10 pacientes con artritis cronica juvenil (acj) tratados con acido acetilsalicilico cada 12 horas.  se comprobo que existia una gran variabilidad interindividual, en ambas concentraciones, en el grupo de pacientes estudiados. Se demostro una buena correlacion lineal entre la csas y la cpast con un r=0.74. La relacion csas\/cpast vario ampliamente entre los 10 pacientes y no se mantuvo constante en ninguno de ellos, a lo largo de un intervalo de 12 horas. Creemos que la monitorizacion indirecta de la cpast, a traves de la saliva, puede resultar util como control del tratamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinacion de la concentracion plasmatica y salivar de salicilato, en ni\u00f1os con artritis cronica juvenil, mediante cromatografia liquida de alta resolucion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinacion de la concentracion plasmatica y salivar de salicilato, en ni\u00f1os con artritis cronica juvenil, mediante cromatografia liquida de alta resolucion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elia Acitores Suz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Legaz Gonzalez M. Estrella<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Casado De Fr\u00edas Enrique <\/li>\n<li>Jos\u00e9 Quero Jim\u00e9nez (vocal)<\/li>\n<li>Alfonso Moreno Gonzalez (vocal)<\/li>\n<li>Angel Nogales Espert (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elia Acitores Suz Para evitar las repetidas venopunciones practicadas a los pacientes con artritis cronica juvenil, en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,986,139,161,877],"tags":[3585,7781,23687,269180,7519,162366],"class_list":["post-155133","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-complutense-de-madrid","category-medicina-interna","category-pediatria","category-reumatologia","tag-alfonso-moreno-gonzalez","tag-angel-nogales-espert","tag-casado-de-frias-enrique","tag-elia-acitores-suz","tag-jose-quero-jimenez","tag-legaz-gonzalez-m-estrella"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=155133"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155133\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=155133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=155133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=155133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}