{"id":15529,"date":"2002-08-02T00:00:00","date_gmt":"2002-08-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-administracion-de-interleucina-2-sobre-la-endometriosis-experimentalmente-inducida-en-la-rata-wistar\/"},"modified":"2002-08-02T00:00:00","modified_gmt":"2002-08-02T00:00:00","slug":"efecto-de-la-administracion-de-interleucina-2-sobre-la-endometriosis-experimentalmente-inducida-en-la-rata-wistar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-administracion-de-interleucina-2-sobre-la-endometriosis-experimentalmente-inducida-en-la-rata-wistar\/","title":{"rendered":"Efecto de la administraci\u00f3n de interleucina-2 sobre la endometriosis experimentalmente inducida en la rata wistar"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Bermejo De Las Heras Rosa <\/strong><\/h2>\n<p>La endometriosis es todav\u00eda en la actualidad una enfermedad de etiopatogenia desconocida, y por ello el tratamiento sigue siendo paliativo. Las alteraciones del sistema inmune est\u00e1n presentes en las pacientes con endometriosis y, aunque a\u00fan no se conoce si su d\u00e9ficit es la causa o si s\u00f3lo participa en el mantenimiento y avance de la enfermedad, parece clara que participan en la patogenia de la endometriosis. Los tratamientos inmunomoduladores podr\u00edan constituir una nueva v\u00eda terap\u00e9utica. La endometriosis experimentalmente inducida en la rata wistar constituye un buen modelo para el ensayo de nuevos tratamientos puesto que parece comportarse de manera similar a la enfermedad humana en muchos aspectos. Bas\u00e1ndonos en esto, elaboramos nuestra hip\u00f3tesis: la interleucemia 2 produce una disminuci\u00f3n del tama\u00f1o de los implantes endometri\u00f3sicos inducidos experimentalmente en la rata wistar, y este efecto se prolonga en el tiempo. Para ello, se ha dise\u00f1ado un estudio experimental, aleatorio, controlado con placebo, longitudinal y prospectivo sobre un modelo experimental. Adem\u00e1s fue un estudio doble ciego pues, en el momento de la evaluaci\u00f3n del tama\u00f1o de los implantes, el investigador no conoci\u00f3 a qu\u00e9 grupo pertenec\u00eda el animal ni el f\u00e1rmaco utilizado.  el estudio se planific\u00f3 en cuatro experimentos individuales:  primer experimento, dise\u00f1ado para determinar s\u00ed la il-2 administrada intraperitonealmente disminuye la endometriosis experimental. Se indujo endometriosis experimental a un grupo de sesenta ratas; al mes se realiz\u00f3 una segunda laparotom\u00eda o laparatom\u00eda de evaluaci\u00f3n de la endometriosis. aleatoriamente se dividieron en tres subgrupos (n=20), administrando a uno de ellos 15.000 ui de il-2 humana, a otro 15.000 ui de il-2 espec\u00edfica de rata y al grupo restante placebo. Al mes se llev\u00f3 a cabo una nueva laparotom\u00eda de evaluaci\u00f3n (tercera). Se administr\u00f3 una nueva dosis de il-2 humana, il-2 de rata o placebo seg<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la administraci\u00f3n de interleucina-2 sobre la endometriosis experimentalmente inducida en la rata wistar<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la administraci\u00f3n de interleucina-2 sobre la endometriosis experimentalmente inducida en la rata wistar <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Bermejo De Las Heras Rosa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Quereda Segu\u00ed<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Acien alvarez <\/li>\n<li>Rafael Comino delgado (vocal)<\/li>\n<li>Juan Gimenez fern\u00e1ndez (vocal)<\/li>\n<li>lorenzo Abad Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bermejo De Las Heras Rosa La endometriosis es todav\u00eda en la actualidad una enfermedad de etiopatogenia desconocida, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,135,37169,156,1323],"tags":[49488,49489,49490,5494,11993,1675],"class_list":["post-15529","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-ginecologia","category-miguel-hernandez-de-elche","category-patologia","category-patologia-experimental","tag-bermejo-de-las-heras-rosa","tag-francisco-quereda-segui","tag-juan-gimenez-fernandez","tag-lorenzo-abad-Martinez","tag-pedro-acien-alvarez","tag-rafael-comino-delgado"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15529"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15529\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}