{"id":155388,"date":"2026-01-12T17:19:49","date_gmt":"2026-01-12T17:19:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aproximacion-a-la-sintesis-del-fragmento-espiroacetalico-de-avermectinas-y-milbemicinas\/"},"modified":"2026-01-12T17:19:49","modified_gmt":"2026-01-12T17:19:49","slug":"aproximacion-a-la-sintesis-del-fragmento-espiroacetalico-de-avermectinas-y-milbemicinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aproximacion-a-la-sintesis-del-fragmento-espiroacetalico-de-avermectinas-y-milbemicinas\/","title":{"rendered":"Aproximacion a la sintesis del fragmento espiroacetalico de avermectinas y milbemicinas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gomez Lopez Ana M. <\/strong><\/h2>\n<p>Se ha estudiado una aproximacion convergente a partir de d-glucosa para la sintesis enantioselectiva del fragmento espiroacetalico de avermectinas y milremilinas, producto de importante interes farmaceutico y a su vez de gran complejidad estructural. Siguiendo un planteamiento retrosintetico inicial que divide el espiroaletal en dos subestructuras, electrofilo y nucleofilo, se ha desarrollado metodolog\u00eda original que permite obtener cada una de duchas subnidades con la esteroquimica deseada.  asi mismo, y para el acoplamiento final se ha desarrollado un nuevo metodo de formacion de espiroacetales insaturados que implica a)alquilacion estereoselectiva de moglicosidos insaturados con suleatos ciclicos, y b)reaccion de glicosidacion intramolecular en medio neutro.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aproximacion a la sintesis del fragmento espiroacetalico de avermectinas y milbemicinas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aproximacion a la sintesis del fragmento espiroacetalico de avermectinas y milbemicinas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gomez Lopez Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Serafin Alvarez Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Perez Alvarez-ossorio <\/li>\n<li>Manuel Bernab\u00e9 Pajares (vocal)<\/li>\n<li>Benjam\u00edn Rodr\u00edguez Gonz\u00e1lez (vocal)<\/li>\n<li>Jos\u00e9 Luis Garc\u00eda Ruano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gomez Lopez Ana M. Se ha estudiado una aproximacion convergente a partir de d-glucosa para la sintesis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[986,17,416],"tags":[9621,156061,5621,14268,6599,269473],"class_list":["post-155388","post","type-post","status-publish","format-standard","hentry","category-complutense-de-madrid","category-quimica","category-quimica-organica","tag-benjamin-rodriguez-gonzalez","tag-gomez-lopez-ana-m","tag-jose-luis-garcia-ruano","tag-manuel-bernabe-pajares","tag-rafael-perez-alvarez-ossorio","tag-serafin-alvarez-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=155388"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155388\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=155388"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=155388"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=155388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}