{"id":155561,"date":"2026-01-12T17:21:24","date_gmt":"2026-01-12T17:21:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-benzo-de-isoquinolein-13-dionas-con-actividad-antitumoral\/"},"modified":"2026-01-12T17:21:24","modified_gmt":"2026-01-12T17:21:24","slug":"nuevas-benzo-de-isoquinolein-13-dionas-con-actividad-antitumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevas-benzo-de-isoquinolein-13-dionas-con-actividad-antitumoral\/","title":{"rendered":"\u00abnuevas benzo d,e isoquinolein-1,3-dionas con  actividad antitumoral\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marina Moran Moset <\/strong><\/h2>\n<p>Siguiendo la linea de investigacion desarrollada por bra\u00f1a y col. Dirigida a la sintesis de nuevos benzo d,e isoquinolein-1,3-dionas como compuestos con actividad citostatica.  se han preparado compuestos mediante la variacion de los sustituyentes en el cromoforo naftalenico, conjugando las estructuras de los compuestos mas activos de la serie como antitumorales, mitonafide, con grupo nitro y amonafide con grupo amino.  tambien se ha estudiado los efectos sobre la actividad citostatica producidos al modificar la ramificacion en la cadena lateral.  por otra parte, se han sintetizado una serie de bisnaftalimidas con un presumible mecanismo de doble intercalacion.  algunos de los compuestos asi obtenidos presentan actividades \u00abin vitro\u00bb muy superiores a los compuestos modelos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abnuevas benzo d,e isoquinolein-1,3-dionas con  actividad antitumoral\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abnuevas benzo d,e isoquinolein-1,3-dionas con  actividad antitumoral\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marina Moran Moset <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Fernandez Bra\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Perez Alvarez-ossorio <\/li>\n<li>Vicente Gotor Santamar\u00eda (vocal)<\/li>\n<li>Mar\u00eda Del Carmen Avenda\u00f1o L\u00f3pez (vocal)<\/li>\n<li>Juan Espliegues Requena (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marina Moran Moset Siguiendo la linea de investigacion desarrollada por bra\u00f1a y col. Dirigida a la sintesis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,986,604,189,484,17,18],"tags":[269678,17715,24132,6660,6599,6659],"class_list":["post-155561","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-complutense-de-madrid","category-espectroscopia-de-absorcion","category-farmacodinamia","category-mecanismos-de-accion-de-la-quimioterapia","category-quimica","category-quimica-analitica","tag-juan-espliegues-requena","tag-maria-del-carmen-avendano-lopez","tag-marina-moran-moset","tag-miguel-fernandez-brana","tag-rafael-perez-alvarez-ossorio","tag-vicente-gotor-santamaria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=155561"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155561\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=155561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=155561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=155561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}