{"id":155682,"date":"2026-01-12T17:22:35","date_gmt":"2026-01-12T17:22:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-antigenicidad-de-hla-b27-estudios-con-peptidos-sinteticos-variantes-naturales-y-mutagenesis-dirigida\/"},"modified":"2026-01-12T17:22:35","modified_gmt":"2026-01-12T17:22:35","slug":"bases-moleculares-de-la-antigenicidad-de-hla-b27-estudios-con-peptidos-sinteticos-variantes-naturales-y-mutagenesis-dirigida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/bases-moleculares-de-la-antigenicidad-de-hla-b27-estudios-con-peptidos-sinteticos-variantes-naturales-y-mutagenesis-dirigida\/","title":{"rendered":"Bases moleculares de la antigenicidad de hla-b27: estudios con peptidos sinteticos, variantes naturales y mutagenesis dirigida."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rojo Gozalo C. Susana <\/strong><\/h2>\n<p>Los antigenos hla de clase i son proteinas altamente polimorficas que median el reconocimiento de antigenos extra\u00f1os por los linfocitos t citoliticos (ctl). Esta tesis se ha centrado en el estudio del antigeno hla-b27, especialmente relevante por su estrecha relacion con la espondilitis anquilosante. Dentro de la especificidad serologica hla-b27 se han detectado 6 subtipos (b*2701 a b*2706), reconocidos de forma diferencial por anticuerpos y ctl. En esta tesis se han realizado los siguientes estudios:  1.- Analisis de la contribucion de la region hipervariable 63-84 a la aloespecificidad serologica de la molecula. Se realizo mediante la obtencion de antisueros dirigidos contra un peptido sintetico que mimetizaba este segmento de la molecula.  2.- Caracterizacion estructural de los subtipos b*2701 y b*2703 mediante la realizacion de mapas peptidicos comparativos con b*2705 y analisis de secuencia radioquimica de los peptidos de diferencia.  3.- Contribucion de la avidez de ctl humanos alorreactivos en el reconocimiento y lisis de celulas murinas que expresan el antigeno hla-b*2705.  4.- Analisis de la relevancia de cada una de las posiciones polimorficas de los subtipos de b27 en el reconocimiento por ctl. Para ello, se analiza el patron de reactividad de una serie de clones de ctl alorreactivos, especificos de b27, frente a celulas humanas transfectadas con una serie de mutantes de este antigeno.  5.- Analisis comparativo de la reactividad de clones de ctl anti-b27 frente a un panel de mutantes transfectados en celulas humanas y murinas. Los objetivos de este estudio fueron determinar si habia alguna alteracion en los epitopos reconocidos por ctl, tras la expresion de b27 en celulas de raton y si el reconocimiento por ctl alorreactivos implicaba la presencia de peptidos unidos a b27.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases moleculares de la antigenicidad de hla-b27: estudios con peptidos sinteticos, variantes naturales y mutagenesis dirigida.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases moleculares de la antigenicidad de hla-b27: estudios con peptidos sinteticos, variantes naturales y mutagenesis dirigida. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rojo Gozalo C. Susana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio L\u00f3pez De Castro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  De La Fuente Monica <\/li>\n<li>Santiago Rodriguez De Cordoba (vocal)<\/li>\n<li>Manuel Ortiz De Landazuri (vocal)<\/li>\n<li>Antonio Arnaiz Villena (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rojo Gozalo C. Susana Los antigenos hla de clase i son proteinas altamente polimorficas que median el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,986,1737],"tags":[4669,53995,6520,7336,269818,15504],"class_list":["post-155682","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-complutense-de-madrid","category-inmunologia","tag-antonio-arnaiz-villena","tag-de-la-fuente-monica","tag-jose-antonio-lopez-de-castro","tag-manuel-ortiz-de-landazuri","tag-rojo-gozalo-c-susana","tag-santiago-rodriguez-de-cordoba"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=155682"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155682\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=155682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=155682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=155682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}