{"id":15581,"date":"2018-03-09T09:02:48","date_gmt":"2018-03-09T09:02:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-inhibitorio-de-losartan-sobre-la-activacion-de-plaquetas-humanas-y-de-rata-por-el-tromboxano-a2-comparacion-con-otros-antagonistas-de-los-receptores-de-la-angiotensina-ii\/"},"modified":"2018-03-09T09:02:48","modified_gmt":"2018-03-09T09:02:48","slug":"efecto-inhibitorio-de-losartan-sobre-la-activacion-de-plaquetas-humanas-y-de-rata-por-el-tromboxano-a2-comparacion-con-otros-antagonistas-de-los-receptores-de-la-angiotensina-ii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-inhibitorio-de-losartan-sobre-la-activacion-de-plaquetas-humanas-y-de-rata-por-el-tromboxano-a2-comparacion-con-otros-antagonistas-de-los-receptores-de-la-angiotensina-ii\/","title":{"rendered":"Efecto inhibitorio de losart\u00e1n sobre la activaci\u00f3n de plaquetas humanas y de rata por el tromboxano a2. comparaci\u00f3n con otros antagonistas de los receptores de la angiotensina ii"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio N\u00fa\u00f1ez Garc\u00eda <\/strong><\/h2>\n<p>Existen m\u00faltiples factores que intervienen en la formaci\u00f3n de trombos que requieren estrategias terap\u00e9uticas complejas. La activaci\u00f3n plaquetaria juega un papel cr\u00edtico en la g\u00e9nesis de los s\u00edndromes coronarios agudos que afectan, no s\u00f3lo a las plaquetas sino tambi\u00e9n a las c\u00e9lulas endoteliales, leucocitos y eritrocitos. La angiotensina ii es un vasoconstrictor que puede participar en los proceso tromb\u00f3ticos.  en esta tesis se comprueba que las plaquetas expresan receptores de tipo at1 de la angiotensina ii. El losart\u00e1n es un inhibidor no pept\u00eddico de la angiotensina ii. Se demuestra que el losart\u00e1n reduce la agregaci\u00f3n plaquetaria inducida por el an\u00e1logo del tromboxano a2, u46619. Este efecto no se observ\u00f3 con el metabolito de losart\u00e1n, exp 3174. El efecto del losart\u00e1n se valor\u00f3 en ensayos de uni\u00f3n en los que el losart\u00e1n inhib\u00eda competitivamente la uni\u00f3n de (3h)u46619 a plaquetas de una manera dosis-dependiente. El irbesart\u00e1n tambi\u00e9n inhibe el receptor de tromboxano en las plaquetas, un efecto que no se obtuvo con la forma activa del candesart\u00e1n, cv11974, ni con valsart\u00e1n.  estos resultados sugieren que los requerimientos estructurales necesarios para antagonizar el receptor de txa2\/pgh2 plaquetario puede ser distinto de los que est\u00e1n involucrados en el antagonismo de los receptores at1. la relevancia in vivo de los hallazgos in vitro se confirma por el hecho de que la administraci\u00f3n de losart\u00e1n in vivo disminuye la expresi\u00f3n de p-selectiva en plaquetas obtenidas de ratas espont\u00e1neamente hipertensas que desarrollan accidentes cerebrovasculares.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto inhibitorio de losart\u00e1n sobre la activaci\u00f3n de plaquetas humanas y de rata por el tromboxano a2. comparaci\u00f3n con otros antagonistas de los receptores de la angiotensina ii<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto inhibitorio de losart\u00e1n sobre la activaci\u00f3n de plaquetas humanas y de rata por el tromboxano a2. comparaci\u00f3n con otros antagonistas de los receptores de la angiotensina ii <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio N\u00fa\u00f1ez Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio L\u00f3pez Farr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Oya otero <\/li>\n<li>Luis Antonio Alvarez-sala walther (vocal)<\/li>\n<li> Pereda Garc\u00eda Juan  Manuel (vocal)<\/li>\n<li>ricardo Jos\u00e9 Bosch mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio N\u00fa\u00f1ez Garc\u00eda Existen m\u00faltiples factores que intervienen en la formaci\u00f3n de trombos que requieren estrategias terap\u00e9uticas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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