{"id":155973,"date":"2026-01-12T17:24:57","date_gmt":"2026-01-12T17:24:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cancer-colo-rectal-estudio-experimental-de-modulacion-del-5-fluoruracilo-tratando-de-potenciar-su-efecto-sobre-tumores-inducidos-por-1-2-di-metil-hidrazina\/"},"modified":"2026-01-12T17:24:57","modified_gmt":"2026-01-12T17:24:57","slug":"cancer-colo-rectal-estudio-experimental-de-modulacion-del-5-fluoruracilo-tratando-de-potenciar-su-efecto-sobre-tumores-inducidos-por-1-2-di-metil-hidrazina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cancer-colo-rectal-estudio-experimental-de-modulacion-del-5-fluoruracilo-tratando-de-potenciar-su-efecto-sobre-tumores-inducidos-por-1-2-di-metil-hidrazina\/","title":{"rendered":"\u00abcancer colo-rectal:  estudio experimental de modulacion del 5-fluoruracilo tratando de potenciar su efecto sobre tumores inducidos por 1-2-di-metil-hidrazina\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Alvarez Alvarez <\/strong><\/h2>\n<p>Basados en la inesperada buena evolucion observada en un paciente con cancer de sigmoides, en un estadio d de dukes, al que se le practico cirugia paliativa, incluida la reseccion del ileon terminal por estar infiltrado y que posteriormente recibio 5-fluoruracilo (5-fu) semanal, se concibio la idea de que la no absorcion de la vitamina b12 pudo potenciar el efecto antitumoral del 5-fu. Por esta razon se ideo un estudio experimental en ratas wistar con canceres colo-rectales inducidos por 1-2-di-metil-hidrazina (dmh). Una vez biopsiadas todas las ratas, se trataron con 5-fu semanal. La derivacion yeyuno-colica practicada, no hizo descender las cifras sericas de vitamina b12 y de fe lo suficiente como para potenciar el efecto antitumoral del 5-fu y la supervivencia fue menor que en el grupo de control (tratado con 5-fu sin derivacion yeyuno-colica). En un grupo tratado con las mismas dosis de 5-fu semanal, pero precedida cada una de ellas por la inhalacion de una mezcla de n2o y o2, se consiguio una erradicacion de los tumores, en el estudio histologico de todo el colon, al menos en un 13,63% del grupo. Este hallazgo parece confirmar que la inhibicion de la vitamina b12 con n2o es capaz de potenciar el efecto antitumoral del 5-fu hasta el punto de erradicar tumores colicos inducidos por dmh en ratas wistar.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abcancer colo-rectal:  estudio experimental de modulacion del 5-fluoruracilo tratando de potenciar su efecto sobre tumores inducidos por 1-2-di-metil-hidrazina\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abcancer colo-rectal:  estudio experimental de modulacion del 5-fluoruracilo tratando de potenciar su efecto sobre tumores inducidos por 1-2-di-metil-hidrazina\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Alvarez Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Garcia Moran Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Lorenzo Fernandez <\/li>\n<li>Carlos Moreno Gonzalez-bueno (vocal)<\/li>\n<li>Aurora Astudillo Gonzalez (vocal)<\/li>\n<li>Reinerio Rodriguez Fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Alvarez Alvarez Basados en la inesperada buena evolucion observada en un paciente con cancer de sigmoides, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,1279,8846,156,1323],"tags":[8872,30208,57541,122734,898,9290],"class_list":["post-155973","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","category-oviedo","category-patologia","category-patologia-experimental","tag-aurora-astudillo-gonzalez","tag-carlos-moreno-gonzalez-bueno","tag-daniel-alvarez-alvarez","tag-manuel-garcia-moran-lopez","tag-pedro-lorenzo-fernandez","tag-reinerio-rodriguez-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=155973"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/155973\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=155973"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=155973"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=155973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}