{"id":156024,"date":"2026-01-12T17:25:23","date_gmt":"2026-01-12T17:25:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-con-citostaticos-en-el-carcinoma-epidermoide-de-cabeza-y-cuello-factores-pronosticos\/"},"modified":"2026-01-12T17:25:23","modified_gmt":"2026-01-12T17:25:23","slug":"tratamiento-con-citostaticos-en-el-carcinoma-epidermoide-de-cabeza-y-cuello-factores-pronosticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-con-citostaticos-en-el-carcinoma-epidermoide-de-cabeza-y-cuello-factores-pronosticos\/","title":{"rendered":"Tratamiento con citostaticos en el carcinoma epidermoide de cabeza y cuello. factores pronosticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Roberto Fernandez Martinez <\/strong><\/h2>\n<p>Bajo la denominacion cancer de cabeza y cuello (ccc) se incluyen una serie heterogenea de tumores localizados en las vias aerodigestivas altas que poseen diferente pronostico y comportamiento en funcion de cada localizacion. Los resultados terapeuticos obtenidos con cirugia (cx) y\/o radioterapia (rt) parecen haber alcanzado un techo sin que se hayan descubierto alternativas mas eficaces. La quimioterapia (qt) posee una elevada actividad antitumoral, aunque los resultados de los ensayos clinicos existentes no permiten establecer un papel definitivo para este tipo de tratamiento frente al ccc.  el objetivo principal de esta tesis es la investigacion de los factores pronosticos de respuesta a la qt y de supervivencia en pacientes con ccc tratados con qt de forma paliativa (grupo paliativo), o como tratamiento de induccion previo a un tratamiento locorregional de intencion radical con cx y\/o rt (g. Neoadyuvante). Para ello se han incluido 366 pacientes en 8 ensayos clinicos diferentes y se han estudiado: 1) la toxicidad producida por el tratamiento, 2) los efectos terapeuticos observados, 3) la influencia de diversos factores en la respuesta a la qt (edad, sexo, estado general del paciente-eg-, esquema de qt utilizado, localizacion del tumor primario, grado de diferenciacion histologica, tama\u00f1o del tumor primario t, tama\u00f1o de las adenopatias -n-, estadio, valores de la hemoglobina -hb- y de la albumina -alb- al inicio del tratamiento, tratamientos previos recibidos, grado de leucopenia producido por la qt y dosis de qt. 4) la influencia de diversos factores en la supervivencia libre de enfermedad (sle) y en la supervivencia global (sg) de los pacientes (la respuesta observada con la qt, la realizacion de cx, la respuesta a la rt y la dosis administrada de rt, ademas de los analizados en 3).  los esquemas de qt utilizados en los distintos ensayos clinicos fueron los siguientes: g. Paliativo: 1) mtx 30 mg\/m2 semanal, 2) pf=cddf 100<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento con citostaticos en el carcinoma epidermoide de cabeza y cuello. factores pronosticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento con citostaticos en el carcinoma epidermoide de cabeza y cuello. factores pronosticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Roberto Fernandez Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Reinerio Rodriguez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Arribas Castrillo Jos\u00e9 Manuel <\/li>\n<li>Jaime Sanz Ortiz (vocal)<\/li>\n<li> Garc\u00eda Puche Jos\u00e9 Luis (vocal)<\/li>\n<li>Manuel Garcia Moran (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Roberto Fernandez Martinez Bajo la denominacion cancer de cabeza y cuello (ccc) se incluyen una serie heterogenea [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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