{"id":156119,"date":"2026-01-12T17:26:17","date_gmt":"2026-01-12T17:26:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diabetes-mellitus-insulino-dependiente-estudio-inmunologico-y-genetico-en-ninos-asturianos\/"},"modified":"2026-01-12T17:26:17","modified_gmt":"2026-01-12T17:26:17","slug":"diabetes-mellitus-insulino-dependiente-estudio-inmunologico-y-genetico-en-ninos-asturianos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diabetes-mellitus-insulino-dependiente-estudio-inmunologico-y-genetico-en-ninos-asturianos\/","title":{"rendered":"Diabetes mellitus insulino-dependiente: estudio inmunologico y genetico en ni\u00f1os asturianos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique Pe\u00f1a Hernandez <\/strong><\/h2>\n<p>La diabetes mellitus insulino-dependiente (dmid) es una enfermedad \u00abde por vida\u00bb, con alta preValencia y con importantes complicaciones y secuelas que aparecen con frecuencia en su evolucion cronica, pese a una adecuada terapia insulinica. Por ello cobra especial importancia la prevencion de la dmid, para lo que es fundamental conocer los factores implicados en la etiopatogenia de la misma.  actualmente se han implicado factores viricos, inmunologicos y geneticos en la etiolog\u00eda de la dmid, principalmente los dos ultimos. En la presente tesis se ha investigado, en un grupo de ni\u00f1os diabeticos insulino dependiente, sus hermanos y sus padres el papel de la herencia, mediante el estudio del haplotipo (hla), buscando la presencia de haplotipos de riesgo o ausencia de haplotipos de proteccion, tambien se han investigado posibles alteraciones de la inmunidad humoral, a traves de la deteccion de inmunocomplejos circulantes dirigidos contra el pancreas endocrino (ica), y celular, cuantificando el porcentaje de linfocitos t (dkt3), las subploblaciones de linfocitos t helper (dkt4) y suppressor (dkt8) y el porcentaje de linfocitos t activandos (linfocitos t-ia), en un intento de contribuir al hallazgo de aquel factor o factores que predisponen a la instauracion de la dmid.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Diabetes mellitus insulino-dependiente: estudio inmunologico y genetico en ni\u00f1os asturianos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Diabetes mellitus insulino-dependiente: estudio inmunologico y genetico en ni\u00f1os asturianos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique Pe\u00f1a Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Crespo Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alfredo Blanco Quiros <\/li>\n<li> Coto Cotallo Gil Daniel (vocal)<\/li>\n<li>Carlos Bous\u00f1o Garcia (vocal)<\/li>\n<li>Rafael Palencia Luaces (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique Pe\u00f1a Hernandez La diabetes mellitus insulino-dependiente (dmid) es una enfermedad \u00abde por vida\u00bb, con alta preValencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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