{"id":156263,"date":"2026-01-12T17:27:43","date_gmt":"2026-01-12T17:27:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-cardiovascular-de-analogos-estructurales-de-diltiazem\/"},"modified":"2026-01-12T17:27:43","modified_gmt":"2026-01-12T17:27:43","slug":"estudio-cardiovascular-de-analogos-estructurales-de-diltiazem","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-cardiovascular-de-analogos-estructurales-de-diltiazem\/","title":{"rendered":"Estudio cardiovascular de analogos estructurales de diltiazem"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Prieto Peralta <\/strong><\/h2>\n<p>Los antagonistas de calcio se definen como farmacos cuyas caracteristicas farmacologicas son consecuencia de su capacidad para inhibir la corriente de entrada de calcio a traves de los canales tipo l de la membrana de las celulas excitables. El objetivo de nuestro trabajo ha sido estudiar diez nuevos analogos estructurales de diltiazem a nivel cardiovascular, y comparar sus efectos con los de diltiazem.  todos los compuestos presentan un efecto inotropico negativo, cronotropico negativo y relajante de fibra lisa vascular en experimentos \u00abin vitro\u00bb, asi como un efecto hipotensor y bradicardizante en experimentos \u00abin vivo\u00bb resultando, en general, el producto mas activo mr-14134.  siempre diltiazem presento mayor actividad.  los experimentos de captacion de 45ca en aorta de rata confirman que mr-14134 bloquea la entrada de calcio a traves de los canales voltaje-dependientes y receptor-dependientes sin afectar la difusion pasiva de calcio.  la inhibicion de la hipotension y la bradicardia que produce mr-14134 por la administracion previa de yohimbina y prazosina, nos hace pensar en una posible participacion de los receptores alfa-adrenergicos en las respuestas observadas en animal entero con este producto.  los resultados obtenidos en rata desmedulada y descerebrada, asi como los obtenidos tras la administracion i.C.V. De mr-14134,indican que existe una participacion del snc en este efecto hipotensor y bradicardizante.  los estudios de fijacion con 3h-clonidina ponen de manifiesto la falta de afinidad tanto de diltiazem como de mr-14134, por el subtipo alfa-2a en corteza cerebral dke rata.  ninguna de las modificaciones estructurales hechas en la molecula de benzotiazepina, respecto a diltiazem, ha dado lugar a la obtencion de compuestos mas activos que el farmaco patron diltiazem.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio cardiovascular de analogos estructurales de diltiazem<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio cardiovascular de analogos estructurales de diltiazem <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Prieto Peralta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis San Rom\u00e1n Del Barrio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Luis Tamargo Men\u00e9ndez <\/li>\n<li>Francisco Orallo Cambeiro (vocal)<\/li>\n<li> Giralt Rue M. Teresa (vocal)<\/li>\n<li>Marina Gordaliza Escobar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Prieto Peralta Los antagonistas de calcio se definen como farmacos cuyas caracteristicas farmacologicas son consecuencia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,9740,9386],"tags":[6260,28225,4665,7196,21161,270372],"class_list":["post-156263","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-sinteticos","category-salamanca","tag-francisco-orallo-cambeiro","tag-giralt-rue-m-teresa","tag-juan-luis-tamargo-menendez","tag-luis-san-roman-del-barrio","tag-marina-gordaliza-escobar","tag-pilar-prieto-peralta"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/156263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=156263"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/156263\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=156263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=156263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=156263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}