{"id":15628,"date":"2018-03-09T09:02:52","date_gmt":"2018-03-09T09:02:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/linfoma-esplenico-de-la-zona-marginal-alteraciones-molculares-caracteristicas\/"},"modified":"2018-03-09T09:02:52","modified_gmt":"2018-03-09T09:02:52","slug":"linfoma-esplenico-de-la-zona-marginal-alteraciones-molculares-caracteristicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/linfoma-esplenico-de-la-zona-marginal-alteraciones-molculares-caracteristicas\/","title":{"rendered":"Linfoma esplenico de la zona marginal. alteraciones molculares caracteristicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mateo Guerrero M. Sol <\/strong><\/h2>\n<p>Esta tesis contribuye de forma significativa en la comprensi\u00f3n, el diagnostico y el tratamiento de linfomas b esplenicos de la zona marginal. Las aportaciones originales de esta tesis han sido:  -la identificaci\u00f3n de marcadores moleculares que permiten diferenciar al linfoma espl\u00e9nico de la zona marginal de otros linfoproliferativos b.  la inestabilidad de microsat\u00e9lites no es una caracteristica molecualar de los lezm frente a un 25% de casos de linfomas malt con inestavilidad de microsatelites.  se observa p\u00e9rdida al\u00e9lica en la regi\u00f3n cromos\u00f3mica 7q31-32 en el 40% de los lezm frente a un 7.7% en otros linfomas b de celula peque\u00f1a.  -el reconocimiento de la existencia de una heterogeneidad molecular clinicamente significativa dentro de esta enfermedad.  el an\u00e1lisis de mutaciones som\u00e1ticas en los genes bcl-6 e igvh demuestra una heterogeneidadmolecular en este tumor, con un 49% de lezm sin mutaciones som\u00e1ticas del gen igv h frente a un 51% de casos mutados. Los casos que presentan mutaciones para el gen igv h tienen mejor pronostico y adem\u00e1s un menor frecuencia de deleci\u00f3n cromos\u00f3mica en 7q.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Linfoma esplenico de la zona marginal. alteraciones molculares caracteristicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Linfoma esplenico de la zona marginal. alteraciones molculares caracteristicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mateo Guerrero M. Sol <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Piris Pinilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Rodr\u00edguez peralto <\/li>\n<li>Juan  cruz Cigudosa garcia (vocal)<\/li>\n<li>estela Matutes Juan (vocal)<\/li>\n<li>francesc Sole ristol (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mateo Guerrero M. Sol Esta tesis contribuye de forma significativa en la comprensi\u00f3n, el diagnostico y el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[49760,49761,19058,49759,49758,30250],"class_list":["post-15628","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-estela-matutes-juan","tag-francesc-sole-ristol","tag-jose-luis-rodriguez-peralto","tag-juan-cruz-cigudosa-garcia","tag-mateo-guerrero-m-sol","tag-miguel-angel-piris-pinilla"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15628"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15628\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}