{"id":15629,"date":"2018-03-09T09:02:52","date_gmt":"2018-03-09T09:02:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-cla%c2%adnicas-e-inmuno-virologicas-de-las-nuevas-terapias-antirretrovirales-en-la-transmision-vertical-del-vih-1\/"},"modified":"2018-03-09T09:02:52","modified_gmt":"2018-03-09T09:02:52","slug":"implicaciones-cla%c2%adnicas-e-inmuno-virologicas-de-las-nuevas-terapias-antirretrovirales-en-la-transmision-vertical-del-vih-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicaciones-cla%c2%adnicas-e-inmuno-virologicas-de-las-nuevas-terapias-antirretrovirales-en-la-transmision-vertical-del-vih-1\/","title":{"rendered":"Implicaciones cl\u00ednicas e inmuno-virol\u00f3gicas de las nuevas terapias antirretrovirales en la transmisi\u00f3n vertical del vih-1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Angeles Mu\u00f1oz Fernandez <\/strong><\/h2>\n<p>A toda mujer embarazada se le debe hacer una prueba de screening para el vih y aquellas que tengan pruebas serol\u00f3gicas de diagn\u00f3stico indeterminado se debe realizar t\u00e9cnicas de detecci\u00f3n directa del virus como la pcr y el aislamiento del vih en cultivo. La incidencia de transmisi\u00f3n vertical del vih s\u00f3lo se detect\u00f3 en las madres embarazadas que no recibieron tratamiento ar y est\u00e1 relacionado con virus con cin\u00e9tica de replicaci\u00f3n r\/a y carga viral mayor de 2.000 copias\/ml. Sin embargo, tanto el tratamiento con zdv como con terapia antirretroviral combinada o de alta eficacia evit\u00f3 la transmisi\u00f3n del virus de la madre al hijo, independientemente de los valores de carga viral e incluso en los aislados resistentes a la zdv. Las mujeres embarazadas infectadas por el vih tratadas con terapia combinada tuvieron menos de 2000 copias\/ml de carga viral en el momento del parto. Muy importante rese\u00f1ar que las madres que fueron tratadas en monoterapia con zdv tuvieron aislados virales con la mutaci\u00f3n pol 215 que est\u00e1 relacionado en conferir alta resistentes a la zdv, siendo perjudicial en la evoluci\u00f3n cl\u00ednica de la madre, por lo que se debe evitar el tratamiento en monoterapia. Los ni\u00f1os de madres que no recibieron tratamientos antirretrovirales tuvieron la mutaciones en el gen pol del vih relacionadas con resistencia a antirretrovirales en ausencia de selecci\u00f3n positiva por los antirretrovirales y lo m\u00e1s importante es que la terapia antirretroviral de alta eficacia que incluye ip no ha mostrado efectos adversos severos en las madres y ha mostrado seguridad en los ni\u00f1os hasta la edad de los 12 meses y ha evitado la transmisi\u00f3n del vih en todos los ni\u00f1os analizados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones cl\u00ednicas e inmuno-virol\u00f3gicas de las nuevas terapias antirretrovirales en la transmisi\u00f3n vertical del vih-1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones cl\u00ednicas e inmuno-virol\u00f3gicas de las nuevas terapias antirretrovirales en la transmisi\u00f3n vertical del vih-1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Angeles Mu\u00f1oz Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Villa El\u00edzaga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Nogales espert <\/li>\n<li>eduardo Domenech (vocal)<\/li>\n<li>Manuel Fresno escudero (vocal)<\/li>\n<li>raul Ortiz de lejarazu leonardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Angeles Mu\u00f1oz Fernandez A toda mujer embarazada se le debe hacer una prueba de screening para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1085,139,156,2935],"tags":[7781,49762,17798,30047,22625,4947],"class_list":["post-15629","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-enfermedades-infecciosas","category-medicina-interna","category-patologia","category-sindrome-de-inmunodeficiencia-adquirida","tag-angel-nogales-espert","tag-eduardo-domenech","tag-ignacio-villa-elizaga","tag-m-angeles-munoz-fernandez","tag-manuel-fresno-escudero","tag-raul-ortiz-de-lejarazu-leonardo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15629"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15629\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15629"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15629"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}