{"id":15632,"date":"2018-03-09T09:02:52","date_gmt":"2018-03-09T09:02:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-apoptosis-por-el-oncogen-bcr-abl-en-leucemia-mieloide-cronica-mecanismos-de-quimiorresistencia\/"},"modified":"2018-03-09T09:02:52","modified_gmt":"2018-03-09T09:02:52","slug":"regulacion-de-la-apoptosis-por-el-oncogen-bcr-abl-en-leucemia-mieloide-cronica-mecanismos-de-quimiorresistencia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/regulacion-de-la-apoptosis-por-el-oncogen-bcr-abl-en-leucemia-mieloide-cronica-mecanismos-de-quimiorresistencia\/","title":{"rendered":"Regulaci\u00f3n de la apoptosis por el oncogen bcr\/abl en leucemia mieloide cr\u00f3nica: mecanismos de quimiorresistencia"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Horita Gonz\u00e1lez Sandra Machiko <\/strong><\/h2>\n<p>La leucemia mieloide cr\u00f3nica (lmc) es un desorden mieloproliferativo clonal resultado de la transformaci\u00f3n neopl\u00e1sica de una c\u00e9lula madre hematopoy\u00e9tica, caracterizada por la presencia del cromosoma filadelfia, o translocaci\u00f3n rec\u00edproca entre los cromosomas 9 y 22 en una c\u00e9lula madre hematopoy\u00e9tica, que fusiona parte del gen bcr con parte del gen abl. Este gen quim\u00e9rico va a dar lugar a una prote\u00edna de 210 kd caracter\u00edsticas de la lmc, y que posee una elevada actividad tirosina quinasa, fundamental en la capacidad transformante de bcr-abl. Una caracter\u00edstica de estas c\u00e9lulas es la mayor resistencia a la apoptosis que est\u00e1 asociada con un aumento en la expresi\u00f3n y\/o activaci\u00f3n de numerosos efectores como ras, pi-3k, akt, stats, &#8230; En este trabajo nosotros proponemos la ruta bcr-abl\/stat5\/bclxl como una ruta principal de supervivencia tanto en l\u00edneas celulares que expresan bcr-abl como en c\u00e9lulas primarias de pacientes de lmc en fase cr\u00f3nica y en crisis bl\u00e1stica. Por supuesto esta no es la \u00fanica ruta que mantiene la supervivencia de estas c\u00e9lulas, otra v\u00eda como es la de nf-kb tambi\u00e9n hemos visto que contribuye al aumento en la expresi\u00f3n de bclxl. Para este trabajo hemos empleado un dominante negativo de stat5 as\u00ed como un inhibidor espec\u00edfico de la actividad quinasa de bcr-abl, sti571, que induce la muerte de la c\u00e9lula con disminuci\u00f3n en la expresi\u00f3n de bcl-xl. En este proceso apopt\u00f3tico hay expresi\u00f3n de una prote\u00edna letal, hrk, que en condiciones normales debe mantenerse reprimida. En nuestro modelo, la prote\u00edna represora dream parece impedir la transcripci\u00f3n de hrk. Por \u00faltimo hemos estudiado posibles mecanismos de resistencia al sti571 que ya se emplea exitosamente en el tratamiento de la lmc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la apoptosis por el oncogen bcr\/abl en leucemia mieloide cr\u00f3nica: mecanismos de quimiorresistencia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la apoptosis por el oncogen bcr\/abl en leucemia mieloide cr\u00f3nica: mecanismos de quimiorresistencia <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Horita Gonz\u00e1lez Sandra Machiko <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Fernandez Luna<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Le\u00f3n serrano <\/li>\n<li>rosario Perona abellon (vocal)<\/li>\n<li>joan Gil santano (vocal)<\/li>\n<li>felipe Luis Prosper cardoso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Horita Gonz\u00e1lez Sandra Machiko La leucemia mieloide cr\u00f3nica (lmc) es un desorden mieloproliferativo clonal resultado de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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