{"id":156390,"date":"2026-01-12T17:28:56","date_gmt":"2026-01-12T17:28:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-inmunorregulador-de-la-il-4-sobre-los-linfocitos-con-actividad-killer\/"},"modified":"2026-01-12T17:28:56","modified_gmt":"2026-01-12T17:28:56","slug":"efecto-inmunorregulador-de-la-il-4-sobre-los-linfocitos-con-actividad-killer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-inmunorregulador-de-la-il-4-sobre-los-linfocitos-con-actividad-killer\/","title":{"rendered":"Efecto inmunorregulador de la il-4 sobre los linfocitos con actividad killer."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Bello Fernandez M. Concepcion <\/strong><\/h2>\n<p>Linfocitos con actividad killer circulante (ak) secretores de tnf y de g-ifn, son producidos espontaneamente despues del tmo, y tambien son generados en presencia de il-2. Hemos investigado si la il-4 regula negativamente mecanismos efectores citotoxicos dependientes de esta funcion. Los resultados demuestran que la il-4 esta ausente en el suero de donantes, y presente en el suero de 7\/9 paciente tmo. Durante la infusion de il-2, la produccion de il-4 se ha demostrado a nivel de mrna e \u00abin situ\u00bb mediante inmunofluorescencia.  en el grupo control, la il-4 exogena no induce actividad ak e inhibe significativamente (p=0.002) la funcion lak inducida por il-2. Este efecto fue muy limitado tanto en tmo como en pacientes con il-2. La funcion nk tampoco experimento cambios valorables.  estudios con anticuerpos anti-il-4 han demostrado que la il-4 endogena regula la duracion e intensidad de la actividad ak.  asimismo, la il-4 disminuye significativamente la produccion de tnf y g-ifn (p 0.05), inducida por il-2, tanto en el grupo control como en pacientes. El bloqueo de la il-4 endogena ocasiona un incremento significativo de los niveles de g-ifn y de tnf (p&lt;0.05). En conclusion, la il-4 es uno de los mecanismos homeostacos implicados en la regulacion de la funcion ak y de las citoquinas que producen.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto inmunorregulador de la il-4 sobre los linfocitos con actividad killer.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto inmunorregulador de la il-4 sobre los linfocitos con actividad killer. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Bello Fernandez M. Concepcion <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Zubizarreta Ypi\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Gonzalez  Macias <\/li>\n<li>Alberto Gra\u00f1ena Batista (vocal)<\/li>\n<li> De La Hera Antonio (vocal)<\/li>\n<li>Antonio Torres G\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bello Fernandez M. Concepcion Linfocitos con actividad killer circulante (ak) secretores de tnf y de g-ifn, son [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10518,35,1737],"tags":[219,239238,29697,270484,15112,9586],"class_list":["post-156390","post","type-post","status-publish","format-standard","hentry","category-cantabria","category-ciencias-de-la-vida","category-inmunologia","tag-alberto-granena-batista","tag-alberto-zubizarreta-ypina","tag-antonio-torres-gomez","tag-bello-fernandez-m-concepcion","tag-de-la-hera-antonio","tag-jesus-gonzalez-macias"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/156390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=156390"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/156390\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=156390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=156390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=156390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}